Dnm1 - dynamin 1 Gene

种属: Rattus norvegicus

同用名: Dnm

基因 ID: 140694 | 基因类型: protein coding

关于 Dnm1

功能概要

Enables several functions, including D2 Dopamine Receptor binding activity; SH3 domain binding activity; and nitric-oxide synthase binding activity. Involved in G protein-coupled receptor internalization; positive regulation of synaptic vesicle endocytosis; and response to amyloid-beta. Located in several cellular components, including Golgi apparatus; synaptic vesicle; and varicosity. Part of protein-containing complex. Is active in presynaptic endocytic zone membrane. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 31. Orthologous to human DNM1 (Dynamin 1). [provided by Alliance of Genome Resources, Apr 2022]

Dnm1 基因产物(1)

mRNA	Protein	Name
NM_080689.5	NP_542420.1	dynamin-1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables D2 dopamine receptor binding	IPI IPI: 通过物理相互作用推断	14709338	RGD
enables SH3 domain binding	IDA IDA: 通过直接分析推断	16648848	RGD
enables SH3 domain binding	IPI IPI: 通过物理相互作用推断	9348539	RGD
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16432212	RGD
enables nitric-oxide synthase binding	IPI IPI: 通过物理相互作用推断	21490139	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	9238017	RGD
enables protein serine/threonine kinase binding	IPI IPI: 通过物理相互作用推断	20802490	RGD
enables protein-containing complex binding	IDA IDA: 通过直接分析推断	17257598	RGD
enables protein-containing complex binding	IPI IPI: 通过物理相互作用推断	9348539	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled receptor internalization	IMP IMP: 通过突变表型推断	14709338	RGD
involved in positive regulation of synaptic vesicle endocytosis	IMP IMP: 通过突变表型推断	17437541	RGD
involved in positive regulation of synaptic vesicle recycling	IMP IMP: 通过突变表型推断	17880892	RGD
involved in receptor internalization	IMP IMP: 通过突变表型推断	11100149	RGD
involved in receptor-mediated endocytosis	IMP IMP: 通过突变表型推断	12011079	RGD
involved in regulation of synaptic vesicle endocytosis	IMP IMP: 通过突变表型推断	16648848	RGD
involved in response to amyloid-beta	IEP IEP: 通过表达模式推断	20847448	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	9725914	RGD
located in clathrin-coated vesicle	IDA IDA: 通过直接分析推断	9725914	RGD
located in endocytic vesicle	IDA IDA: 通过直接分析推断	17257598	RGD
located in presynapse	IDA IDA: 通过直接分析推断	9238017	RGD
is active in presynaptic endocytic zone membrane	IDA IDA: 通过直接分析推断	7877693	RGD
part of protein-containing complex	IDA IDA: 通过直接分析推断	17257598	RGD
located in synaptic vesicle	IDA IDA: 通过直接分析推断	12646135	RGD
located in varicosity	IDA IDA: 通过直接分析推断	12646135	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

dynamin-1

B-dynamin	D100
dynamin, brain

Dnm1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	Dnm1	P21575	Sh3gl2	Rattus norvegicus	O35179	Anti Bait CoIP	17437541
Intra	Dnm1	P21575	Sh3gl2	Rattus norvegicus	O35179	Pull Down	17437541
Intra	Dnm1	P21575	Sh3gl2	Rattus norvegicus	O35179	Competition Binding	17437541
Intra	Dnm1	P21575	Pacsin1	Rattus norvegicus	Q9Z0W5	Competition Binding	17437541
Intra	Dnm1	P21575	Pacsin1	Rattus norvegicus	Q9Z0W5	Pull Down	17437541
Intra	Dnm1	P21575	Grb2	Rattus norvegicus	P62994	Competition Binding	17437541
Intra	Dnm1	P21575	Grb2	Rattus norvegicus	P62994	Pull Down	17437541
Cross	Dnm1	P21575	MYO1E	Homo sapiens	Q12965	Pull Down	17257598
Cross	Dnm1	P21575	MYO1E	Homo sapiens	Q12965	Anti Bait CoIP	17257598
Intra	Dnm1	P21575	Pik3r1	Rattus norvegicus	Q63787	Pull Down	17437541
Cross	Dnm1	P21575	q5tcz1-2	Homo sapiens	Q5TCZ1-2	ITC	19464300
Intra	Dnm1	P21575	Dnm1	Rattus norvegicus	P21575	TEM	21927001
Intra	Dnm1	P21575	Sorbs2	Rattus norvegicus	O35413	Anti Bait CoIP	19116150
Intra	Dnm1	P21575	Nckipsd	Mus musculus	Q9ESJ4	Pull Down	16221862
Intra	Dnm1	P21575	Dnm1	Rattus norvegicus	P21575	X-Ray Diffraction	21927001
Intra	Dnm1	P21575	Amph	Rattus norvegicus	O08838	Pull Down	17437541
Intra	Dnm1	P21575	Dnm1	Rattus norvegicus	P21575	GMS	21927001
Intra	Dnm1	P21575	Dnm1	Rattus norvegicus	P21575	Density Sedimentation	21927001
Intra	Dnm1	P21575	Amph	Rattus norvegicus	O08838	Pull Down	9348539
Intra	Dnm1	P21575	Dnm1	Rattus norvegicus	P21575	TEM	16432212
Intra	Dnm1	P21575	Dnm1	Rattus norvegicus	P21575	Light Scattering	21927001
Intra	Dnm1	P21575	Dnm1	Rattus norvegicus	P21575	Comigration in SDS	16432212
Intra	Dnm1	P21575	Nckipsd	Mus musculus	Q9ESJ4	Anti Bait CoIP	16221862
Intra	Dnm1	P21575	Bin1	Rattus norvegicus	O08839	Pull Down	9348539
Intra	Dnm1	P21575	Shank1	Rattus norvegicus	Q9WV48	Anti Tag CoIP	11583995
Intra	Dnm1	P21575	Shank1	Rattus norvegicus	Q9WV48	Anti Bait CoIP	11583995

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03903	DNM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS03904	DNM1L Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Dnm1	NCBI	NCBI:1759

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