2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. GW 590735

GW 590735 是一种有效的选择性 PPARα 激动剂。GW 590735 显示 PPARα 上的 EC50=4 nM，与 PPARδ 和 PPARγ 相比，选择性至少为 500 倍。GW 590735 可用于血脂异常的研究。

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GW 590735 Chemical Structure

GW 590735 Chemical Structure

CAS No. : 343321-96-0

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥3300
In-stock
1 mg ￥1200
In-stock
5 mg ￥3000
In-stock
10 mg ￥4000
In-stock
25 mg 现货 询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of GW 590735:

GW 590735 相关抗体

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查看 PPAR 亚型特异性产品:

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PPARα PPARβ/δ PPARγ PPAR PPARδ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GW 590735 is a potent and selective PPARα agonist. GW 590735 showsEC50=4 nM on PPARα and at least 500-fold selectivity versus PPARδ and PPARγ. GW 590735 can be used for the research of dyslipidemia[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CV-1 EC50
> 10 μM
Compound: GW-590735
Agonist activity at human PPARgamma-LBD expressed in CV1 cells co-transfected with Gal4 after 40 hrs by luciferase based transactivation assay
Agonist activity at human PPARgamma-LBD expressed in CV1 cells co-transfected with Gal4 after 40 hrs by luciferase based transactivation assay
[PMID: 21515063]
CV-1 EC50
> 10 μM
Compound: GW-590735
Transactivation of Gal4-fused human PPARgamma DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assay
Transactivation of Gal4-fused human PPARgamma DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assay
[PMID: 21112784]
CV-1 EC50
> 10 μM
Compound: 25a, GW-590735
Agonist potency at PPARgamma in CV1 cells by cell based transient transfection assay
Agonist potency at PPARgamma in CV1 cells by cell based transient transfection assay
[PMID: 17243659]
CV-1 EC50
0.004 μM
Compound: 25a, GW-590735
Agonist potency at PPARalpha in CV1 cells by cell based transient transfection assay
Agonist potency at PPARalpha in CV1 cells by cell based transient transfection assay
[PMID: 17243659]
CV-1 EC50
0.01 μM
Compound: GW-590735
Agonist activity at human PPARalpha-LBD expressed in CV1 cells co-transfected with Gal4 after 40 hrs by luciferase based transactivation assay
Agonist activity at human PPARalpha-LBD expressed in CV1 cells co-transfected with Gal4 after 40 hrs by luciferase based transactivation assay
[PMID: 21515063]
CV-1 EC50
0.01 μM
Compound: GW-590735
Transactivation of Gal4-fused human PPARalpha DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assay
Transactivation of Gal4-fused human PPARalpha DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assay
[PMID: 21112784]
CV-1 EC50
2.6 μM
Compound: GW-590735
Agonist activity at human PPARdelta-LBD expressed in CV1 cells co-transfected with Gal4 after 40 hrs by luciferase based transactivation assay
Agonist activity at human PPARdelta-LBD expressed in CV1 cells co-transfected with Gal4 after 40 hrs by luciferase based transactivation assay
[PMID: 21515063]
CV-1 EC50
2.6 μM
Compound: GW-590735
Transactivation of Gal4-fused human PPARdelta DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assay
Transactivation of Gal4-fused human PPARdelta DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assay
[PMID: 21112784]
CV-1 EC50
2.83 μM
Compound: 25a, GW-590735
Agonist potency at PPARdelta in CV1 cells by cell based transient transfection assay
Agonist potency at PPARdelta in CV1 cells by cell based transient transfection assay
[PMID: 17243659]
体内研究
(In Vivo)

GW 590735 (0.5-5 mg/kg; orally twice a day for 5 days) is able to lower LDLc and triglycerides (TG) and increase HDL cholesterol in the Apo-A-I-transgenic mouse model (male C57BL/6 mice transgenic for human ApoA-I)[1].
GW 590735 (intravenous administration; 2.7 mg/kg; rat) treatment shows Cl, Vd, T1/2, and F% are 5 mL/min/kg, 1 L/kg, 2.4 hours and 47%, respectively[1].
GW 590735 (intravenous administration; 2 mg/kg; dog) treatment shows Cl, Vd, T1/2, and F% are 13 mL/min/kg, 2.8 L/kg, 2.6 hours and 85%, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

478.48

Formula

C23H21F3N2O4S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 250 mg/mL (522.49 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0900 mL 10.4498 mL 20.8995 mL
5 mM 0.4180 mL 2.0900 mL 4.1799 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

GW 590735 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0900 mL 10.4498 mL 20.8995 mL 52.2488 mL
5 mM 0.4180 mL 2.0900 mL 4.1799 mL 10.4498 mL
10 mM 0.2090 mL 1.0450 mL 2.0900 mL 5.2249 mL
15 mM 0.1393 mL 0.6967 mL 1.3933 mL 3.4833 mL
20 mM 0.1045 mL 0.5225 mL 1.0450 mL 2.6124 mL
25 mM 0.0836 mL 0.4180 mL 0.8360 mL 2.0900 mL
30 mM 0.0697 mL 0.3483 mL 0.6967 mL 1.7416 mL
40 mM 0.0522 mL 0.2612 mL 0.5225 mL 1.3062 mL
50 mM 0.0418 mL 0.2090 mL 0.4180 mL 1.0450 mL
60 mM 0.0348 mL 0.1742 mL 0.3483 mL 0.8708 mL
80 mM 0.0261 mL 0.1306 mL 0.2612 mL 0.6531 mL
100 mM 0.0209 mL 0.1045 mL 0.2090 mL 0.5225 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW 590735343321-96-0GW590735GW-590735PPARPeroxisome proliferator-activated receptorsdyslipidemialipidimbalanceHDLctriglyceridesLDLcInhibitorinhibitorinhibit

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产品名称：
GW 590735
目录号：
HY-106278
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