2. Autophagy Cell Cycle/DNA Damage
  3. Autophagy CDK
  4. H1k

H1k 是一种 Eudistomin Y 衍生物，是一种溶酶体靶向抗增殖剂。H1k 增加自噬信号并下调细胞周期蛋白依赖性激酶 (CDK1) 和细胞周期蛋白 B1 的表达。H1k 可用于癌症研究。

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H1k Chemical Structure

H1k Chemical Structure

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H1k 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

H1k, a Eudistomin Y derivative, is a lysosome-targeted antiproliferation agent. H1k increases the autophagy signal and downregulate the expression of cyclin-dependent kinase (CDK1) and cyclin B1. H1k can be used in research of cancer[1].

体外研究
(In Vitro)

H1k (72 h) 对 LS-180、HepG-2、SGC-7901、A549 和 MDA-MB-231 细胞具有抗增殖活性，IC50 值分别为 2.9、9.6、12.1、14.8 和 20.5 μM[1]。
H1k (0-50 μM; 24 h) 以剂量依赖性方式触发 MDA-MB-231 和 SGC-7901 细胞明显的 G2-M 停滞[1]。
H1k (0-20 μM; 6 h; MDA-MB-231 细胞) 诱导自噬发挥其抗增殖活性，溶酶体是其功能靶点[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

H1k 相关抗体:

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 and SGC-7901 cells
Concentration: 0, 5, 10, 20, 50 μM
Incubation Time: 24 hours
Result: Arrested cell cycle at G2-M period in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 and SGC-7901 cells
Concentration: 0, 5, 10, and 20 μM
Incubation Time: 6 hours
Result: Increased the LC3B-I and LC3B-II levels at MDA-MB-231 cells in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 and SGC-7901 cells
Concentration: 0, 5, 10, 20, 50 μM
Incubation Time: 6 hours
Result: Inhibited antiproliferation of cancer cells and the downregulation of CDK1 and cyclin B1.
分子量

392.45

Formula

C26H20N2O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

H1k 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H1kAutophagyCDKCyclin dependent kinaselysosomeantiproliferationcyclin-dependent kinasecyclin B1G2-MInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-149261
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