2. PI3K/Akt/mTOR NF-κB
  3. Akt NF-κB PI3K
  4. Hypoglycemic agent 3

Hypoglycemic agent 3 (Compound H26)，科罗索酸衍生物，具有降脂和显著的降血糖作用，可作为一种降血糖剂。Hypoglycemic agent 3 通过靶向 MCCC1 来抑制胰岛素抵抗，可以用于二型糖尿病的研究。

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Hypoglycemic agent 3 Chemical Structure

Hypoglycemic agent 3 Chemical Structure

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Hypoglycemic agent 3 相关抗体

Top Publications Citing Use of Products

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Akt Akt1 Akt2 Akt3

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hypoglycemic agent 3 (Compound H26), a derivative of corosolic acid, exhibits lipid-lowering and significant hypoglycemic effects and can be used as a hypoglycemic agent. Hypoglycemic agent 3 inhibits insulin resistance by targeting MCCC1 and can be used in the study of type 2 diabetes[1].

体外研究
(In Vitro)

Hypoglycemic agent 3 (Compound H26) (40-320 μM; 24 h) 在 HepG2 细胞中没有表现出明显的细胞毒性[1]。
Hypoglycemic agent 3 (20-40 μM) 主要通过增加 HepG2 细胞中的 MCCC1 来抑制胰岛素抵抗[1]。
Hypoglycemic agent 3 (20 μM; 1 h) 在 HepG2 细胞中显著抑制 Glucosamine (18 mM; 18 h) (HY-B1125) 诱导的葡萄糖生成增加[1]。
Hypoglycemic agent 3 (2.5-20 μM; 1 h) 能激活 PI3K-AKT 并抑制 HepG2 细胞中的 NF-κB 信号通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hypoglycemic agent 3 相关抗体:

Western Blot Analysis[1]

Cell Line: HepG2
Concentration: 2.5, 10, 20 μM
Incubation Time: 1 h
Result: Ehanced the phosphorylation levels of KT and GSK3β.
Sgnificantly increased the expression of IκBα, suggesting that H26 may inhibit the activation of NF-κB.
分子量

529.75

Formula

C32H51NO5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Hypoglycemic agent 3 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hypoglycemic agent 3Hypoglycemic agent3Hypoglycemic agent-3AktNF-κBPI3KPKBProtein kinase BNuclear factor-κBNuclear factor-kappaBPhosphoinositide 3-kinaseType 2 diabetes mellitus (T2DM)HepG2 cellsanti-diabetic activityInhibitorinhibitorinhibit

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