2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Potassium Channel nAChR
  4. Iptakalim hydrochloride

Iptakalim hydrochloride 

目录号: HY-108069 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Iptakalim hydrochloride 是亲脂性的对氨基化合物，是 ATP 敏感的钾通道 (KATP) 的开放剂，也是包含α4β2 的烟碱乙酰胆碱受体 (nAChR)拮抗剂。

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Iptakalim hydrochloride Chemical Structure

Iptakalim hydrochloride Chemical Structure

CAS No. : 642407-63-4

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规格 价格 是否有货 数量
5 mg ￥600
In-stock
10 mg ￥900
In-stock
25 mg ￥1800
In-stock
50 mg ￥2900
In-stock
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200 mg   询价  

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Customer Review

Iptakalim hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Iptakalim hydrochloride, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist[1].

体外研究
(In Vitro)

Iptakalim (Ipt) hydrochloride has been shown to reverse pulmonary resistance vascular remodeling, inhibit proliferation of pulmonary arterial smooth muscle cells (PASMCs) and airway smooth muscle cells (ASMCs), as well as protect PAECs from pathological stimulation[1].
Iptakalim has an inhibitory effect on [Ca2+]cyt increase and the proliferation of pulmonary arterial SMCs induced by endothelin-1 through activation of KATP channels. Iptakalim (10 μM, 10 min) pretreatment of pulmonary arterial SMCs significantly prevents ransient ncrease of [Ca2+]cyt elicited by endothelin-1[2].
Iptakalim at he concentrations of 0.1, 1, and 10 AM lowered[3H]thymidine incorporation by 19.75±4.60% (n=10), 41.20±9.49% (n=10), and 54.74±10.11% (n=10), respectively, compared with that of cells treated only with endothelin-1[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Iptakalim hydrochloride 相关抗体:
体内研究
(In Vivo)

Iptakalim (10-60 mg/kg) attenuates nicotine-evoked conditioned responding. Iptakalim also attenuates chamber activity in these nicotine test sessions[3].
. Iptakalim (60 mg/kg) pretreatment significantly reduced activity (LSD comparisons)[3].
.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Thirty male Sprague-Dawley rats weighing 275-299 grams[3].
Dosage: 0, 10, 30, or 60 mg/kg.
Administration: IP, 10 min before the start of a 4-min test session.
Result: Decreased chamber activity.
Dipper entries following pretreatment with 30 and 60 mg/kg Iptakalim were significantly lower than with 0 (saline) or 10 mg/kg iptakalim pretreatment (Tukey HSD tests).
分子量

179.73

Formula

C9H22ClN
CAS 号
性状

固体

颜色

Yellow to orange

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 25 mg/mL (139.10 mM; 超声助溶 (<70°C))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.5639 mL 27.8195 mL 55.6390 mL
5 mM 1.1128 mL 5.5639 mL 11.1278 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 100 mg/mL (556.39 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥98.0%

COA (261 KB) HNMR (234 KB)

产品使用指南 (1538 KB)
参考文献

Iptakalim hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.5639 mL 27.8195 mL 55.6390 mL 139.0975 mL
5 mM 1.1128 mL 5.5639 mL 11.1278 mL 27.8195 mL
10 mM 0.5564 mL 2.7820 mL 5.5639 mL 13.9098 mL
15 mM 0.3709 mL 1.8546 mL 3.7093 mL 9.2732 mL
20 mM 0.2782 mL 1.3910 mL 2.7820 mL 6.9549 mL
25 mM 0.2226 mL 1.1128 mL 2.2256 mL 5.5639 mL
30 mM 0.1855 mL 0.9273 mL 1.8546 mL 4.6366 mL
40 mM 0.1391 mL 0.6955 mL 1.3910 mL 3.4774 mL
50 mM 0.1113 mL 0.5564 mL 1.1128 mL 2.7820 mL
60 mM 0.0927 mL 0.4637 mL 0.9273 mL 2.3183 mL
80 mM 0.0695 mL 0.3477 mL 0.6955 mL 1.7387 mL
100 mM 0.0556 mL 0.2782 mL 0.5564 mL 1.3910 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Iptakalim642407-63-4Potassium ChannelnAChRKcsANicotinic acetylcholine receptorsKATPAkteNOSpotassiumchannelPASMCInhibitorinhibitorinhibit

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目录号：
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