2. Cytoskeleton Anti-infection
  3. Arp2/3 Complex Fungal
  4. Jasplakinolide

Jasplakinolide 是一种有效的肌动蛋白聚合反应 (actin polymerization) 诱导剂，可以稳定先前存在的肌动蛋白丝。Jasplakinolide 与鬼笔环肽竞争性结合 F-肌动蛋白，Kd 值为 15 nM。Jasplakinolide 是一种来自海洋海绵 (marine sponge) 的天然环状肽，具有抗真菌和抗肿瘤活性。

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Jasplakinolide Chemical Structure

Jasplakinolide Chemical Structure

CAS No. : 102396-24-7

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规格 价格 是否有货
50 μg ￥4500
询问价格 & 货期
100 μg 现货 询问价格 & 货期

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Customer Review

Jasplakinolide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
786-0 GI50
0.02 μM
Compound: 1
Growth inhibition of human 786-0 cells by sulforhodamine B assay
Growth inhibition of human 786-0 cells by sulforhodamine B assay
[PMID: 20121114]
CA46 IC50
0.03 μM
Compound: 5
Antiproliferative activity against human CA46 cells after 24 hrs
Antiproliferative activity against human CA46 cells after 24 hrs
[PMID: 12088429]
CA46 IC50
10 nM
Compound: 1
Growth inhibition of human CA46 cells assessed as induction of actin assembly after 24 hrs
Growth inhibition of human CA46 cells assessed as induction of actin assembly after 24 hrs
[PMID: 20678932]
HCT-116 GI50
0.1 μM
Compound: 1
Growth inhibition of human HCT116 cells by sulforhodamine B assay
Growth inhibition of human HCT116 cells by sulforhodamine B assay
[PMID: 20121114]
HCT-15 GI50
0.69 μM
Compound: 1
Growth inhibition of human HCT15 cells by sulforhodamine B assay
Growth inhibition of human HCT15 cells by sulforhodamine B assay
[PMID: 20121114]
HOP-62 GI50
0.15 μM
Compound: 1
Growth inhibition of human HOP62 cells by sulforhodamine B assay
Growth inhibition of human HOP62 cells by sulforhodamine B assay
[PMID: 20121114]
KB IC50
0.013 μM
Compound: 1, jasplakinolide
Growth inhibition of human KB cells after 72 hrs by CellTiter 96 assay
Growth inhibition of human KB cells after 72 hrs by CellTiter 96 assay
[PMID: 22364566]
M14 GI50
0.056 μM
Compound: 1
Growth inhibition of human M14 cells by sulforhodamine B assay
Growth inhibition of human M14 cells by sulforhodamine B assay
[PMID: 20121114]
OVCAR-3 GI50
0.04 μM
Compound: 1
Growth inhibition of human OVCAR-3 cells by sulforhodamine B assay
Growth inhibition of human OVCAR-3 cells by sulforhodamine B assay
[PMID: 20121114]
SF-539 GI50
0.3 μM
Compound: 1
Growth inhibition of human SF539 cells by sulforhodamine B assay
Growth inhibition of human SF539 cells by sulforhodamine B assay
[PMID: 20121114]
体外研究
(In Vitro)

Jasplakinolide has an IC50 of 35 nM for the antiproliferative effect of jasplakinolide on PC3 prostate carcinoma cells[2].
Jasplakinolide (10 μM; for 2 hours) generates binucleated cells when applied during mitosis. Jasplakinolide induces the formation of F-actin-containing apical extensions in Toxoplasma gondii tachyzoites[2].
Jasplakinolide (1 mM; for 60 min) induces the formation of actin-containing apical extensions in isolated Toxoplasma gondii tachyzoites fixed[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Jasplakinolide 相关抗体:
分子量

709.67

Formula

C36H45BrN4O6
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源

marine sponge
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 10 mg/mL (14.09 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.4091 mL 7.0455 mL 14.0911 mL
5 mM 0.2818 mL 1.4091 mL 2.8182 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.5%

COA (304 KB)

产品使用指南 (1538 KB)
参考文献

Jasplakinolide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4091 mL 7.0455 mL 14.0911 mL 35.2276 mL
5 mM 0.2818 mL 1.4091 mL 2.8182 mL 7.0455 mL
10 mM 0.1409 mL 0.7046 mL 1.4091 mL 3.5228 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Jasplakinolide102396-24-7Arp2/3 ComplexFungalActin-related protein 2/3 complexactinpolymerizationinducerstabilizesF-actinphalloidincyclicpeptidemarinespongefungicidalanti-cancerInhibitorinhibitorinhibit

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目录号：
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