2. Immunology/Inflammation
  3. IRAK
  4. KTX-612

KTX-612 是一种 IRAK4 降解剂，具有口服活性，DC50 值为 7 nM。KTX-612 可用于肿瘤学研究。

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KTX-612 Chemical Structure

KTX-612 Chemical Structure

CAS No. : 2573298-14-1

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KTX-612 相关抗体

Top Publications Citing Use of Products

查看 IRAK 亚型特异性产品:

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IRAK1 IRAK4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KTX-612 is an orally active IRAK4 degrader with a DC50 value of 7 nM. KTX-612 can be used for the research of oncology[1].

IC50 & Target

IRAK4

7 nM (DC50)

体外研究
(In Vitro)

KTX-612 has activity for IRAK4 with a DC50 value of 7 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KTX-612 相关抗体:
体内研究
(In Vivo)

KTX-612 (oral; 10 mg/kg) impacts oral absorption[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[1]
Dosage: 10 mg/kg
Administration: Oral
Result:
Rat PO PK (10 mg/kg) KTX-612
%F 1
AUC(μM*hr) 0.060
分子量

868.94

Formula

C46H51F3N8O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KTX-612 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KTX-6122573298-14-1KTX612KTX 612IRAKInterleukin-1 receptor associated kinaseIL-1R associated kinaseIRAK4degraderactive compoundoncologyInhibitorinhibitorinhibit

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产品名称：
KTX-612
目录号：
HY-148277
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