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  4. Lewis X trisaccharide

Lewis X trisaccharide  (Synonyms: Lewis X)

目录号: HY-N10534 纯度: ≥98.0%
COA 产品使用指南 技术支持

Lewis X trisaccharide (Lewis X, Lex) 是一种强效 TH2 调节剂，拮抗 LPS 诱导的 IL-12 的免疫表达。Lewis X trisaccharide 是人组织血型抗原，在细胞-细胞粘附中起关键作用，是一种肿瘤标志物。Lewis X trisaccharide 也被用于血吸虫病的免疫学研究。

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Lewis X trisaccharide Chemical Structure

Lewis X trisaccharide Chemical Structure

CAS No. : 71208-06-5

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Lewis X trisaccharide 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Lewis X trisaccharide (Lewis X, Lex) is a potent TH2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis[1][2][3].

IC50 & Target

Schistosome

 

体外研究
(In Vitro)

Lewis X trisaccharide-BSA (25 μg/mL; 30 min; before LPS stimulation of 10 ng/mL for 4 h) IL-12p40 and suppresses IL-12p70 protein expression induced by Lipopolysaccharide (LPS, HY-D1056)[1].
Lewis X trisaccharide (2 μM; 30 min; before LPS stimulation of 10 ng/mL for 2 h) decreases nuclear NF-κB concentration in mice bone marrow derived dendritic cells (BDDCs)[1].
Lewis X trisaccharide-BSA (25 μg/mL; 48 h) or Lewis X trisaccharide (5 μg/mL; 48 h) plus ovalbumin (OVA, 25 μg/mL) increases cytokines (IL-4, IL-13, and INF-γ) level in mice splenocytes[1].
Lewis X trisaccharide-containing glycoconjugates stimulates B cells to proliferate and to produce factors that down-regulates the TH1 immune response and up-regulates the TH2 immune response[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lewis X trisaccharide 相关抗体:
体内研究
(In Vivo)

Lewis X trisaccharide ( 5 μg, combinded with 50 μg ovalbumin; s.c.; once a week for 2 weeks) regulates IgE/TH2 responses, and selectively increases the IgE and IgG1 responses in C3H mice, independent of the LPS-TLR4 signaling[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (BALB/c, IL-12 deficient on a BALB/c background, TLR4-defective C3H/hej, or TLR4-wild type C3H/HeOuj mice) (6-8 weeks old)[1]
Dosage: 5 μg, combinded with 50 μg ovalbumin
Administration: Subcutaneous injection; once a week for 2 weeks
Result: In C3H mice, coupled with BSA (LeX-BSA) and elicited higher levels of specific IgE and IgG1, but not IgG2a, which were associated with increased levels of splenic TH2 cytokines when compared with those seen in BSA-sensitized mice.
In BALB/c mice, induced by ovalbumin, significantly increased levels of specific IgE, resulted IgG2a antibodies concomitant with reduced levels of serum IL-12p70.
In IL-12-deficient BALB/c mice, attenuated the downward trend of the above indicators.
分子量

529.49

Formula

C20H35NO15
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源

human
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

H2O 中的溶解度 : ≥ 100 mg/mL (188.86 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8886 mL 9.4430 mL 18.8861 mL
5 mM 0.3777 mL 1.8886 mL 3.7772 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥99.0%

COA (203 KB) 元素分析报告 (220 KB)

产品使用指南 (1538 KB)
参考文献

Lewis X trisaccharide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8886 mL 9.4430 mL 18.8861 mL 47.2152 mL
5 mM 0.3777 mL 1.8886 mL 3.7772 mL 9.4430 mL
10 mM 0.1889 mL 0.9443 mL 1.8886 mL 4.7215 mL
15 mM 0.1259 mL 0.6295 mL 1.2591 mL 3.1477 mL
20 mM 0.0944 mL 0.4722 mL 0.9443 mL 2.3608 mL
25 mM 0.0755 mL 0.3777 mL 0.7554 mL 1.8886 mL
30 mM 0.0630 mL 0.3148 mL 0.6295 mL 1.5738 mL
40 mM 0.0472 mL 0.2361 mL 0.4722 mL 1.1804 mL
50 mM 0.0378 mL 0.1889 mL 0.3777 mL 0.9443 mL
60 mM 0.0315 mL 0.1574 mL 0.3148 mL 0.7869 mL
80 mM 0.0236 mL 0.1180 mL 0.2361 mL 0.5902 mL
100 mM 0.0189 mL 0.0944 mL 0.1889 mL 0.4722 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lewis X trisaccharide71208-06-5Lewis XParasitegangliosideSialyl-Lewis-X tetrasaccharideSLexcell-cell adhesiontumor markerimmunology researchschistosomiasisparasitic diseaseP-selectindendritic cellsC-type lectin receptorInhibitorinhibitorinhibit

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