2. Inhibitory Antibodies
  3. Lintuzumab

Lintuzumab  (Synonyms: 林妥珠单抗; HuM-195)

目录号: HY-P9983

摩尔计算器

Lintuzumab (HUM-195) 是一种抗 CD33人源化单克隆抗体。Lintuzumab 可减少 AML 细胞产生 TNFα 诱导的促炎细胞因子和趋化因子。Lintuzumab 通过抗体依赖性细胞毒性 (ADCC) 和吞噬作用 (ADCP) 活性对 MDR? 和 MDR+ AML 细胞系和原发性 AML 患者样本发挥肿瘤细胞杀伤效果。Lintuzumab 可提高肿瘤小鼠的存活率并减轻肿瘤负担。

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CAS No. : 166089-32-3

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Lintuzumab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lintuzumab (HUM-195) is an anti-CD33 humanized monoclonal antibody. Lintuzumab reduces the production of TNFα-induced pro-inflammatory cytokines and chemokines by AML cells. Lintuzumab promotes tumor cell killing through antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP) activities against MDR? and MDR+ AML cell lines and primary AML patient samples. Lintuzumab enhances survival and reduces tumor burden in mice[1].

同型

Human IgG1 kappa
IC50 & Target

CD33
CAS 号
中文名称

林妥珠单抗
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献

Lintuzumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lintuzumab166089-32-3HuM-195林妥珠单抗HuM195HuM 195OthersAcute myeloid leukemiaAMLADCCADCPInhibitorinhibitorinhibit

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