Losatuxizumab  (Synonyms: ABT-806)

Losatuxizumab (ABT-806) is an anti-EGFR monoclonal antibody. Losatuxizumab binds to EGFR with EC₅₀s of 0.96 nM for EGFR wild-type, 0.09 nM for EGFR^C271A,C283A, 0.12 nM for EGFRvIII, 0.66 nM for EGFR1-501. Losatuxizumab can be used for research of EGFR-expressing cancers^[1][2].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Chimeric; Humanized

Losatuxizumab (0.001 nM-100 nM) 可与表达 EGFRvIII 的细胞系 U87MGde2-7 结合^[1]。
Losatuxizumab 抑制 NR6 huEGFR^C271A,C283A 细胞系中 EGF 介导的 EGFR 磷酸化，IC₅₀ 为 1.2 nM^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lorigerlimab 在多种表达野生型 EGFR 的鳞状细胞癌异种移植模型中均具有抗肿瘤活性^[1]。
Lorigerlimab (40 mg/kg, 腹腔注射) 显着抑制小鼠 U87MGde2-7 肿瘤的生长^[1]。
Lorigerlimab (10 和 40 mg/kg，腹腔注射) 在 PDX GBM 模型 (SN0207 肿瘤) 中延长生存期并降低肿瘤中 pEGFR 水平^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1801544-27-3

液体

Colorless to light yellow

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

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  Human IgG1 kappa

• 
  Immobilized EGFR Protein, Human can bind Losatuxizumab. The EC₅₀ for this effect is 4.085 ng/mL.

• [1]. Reilly EB, et al. Characterization of ABT-806, a Humanized Tumor-Specific Anti-EGFR Monoclonal Antibody. Mol Cancer Ther. 2015 May;14(5):1141-51.  [Content Brief]

  [2]. Phillips AC, et al. ABT-414, an Antibody-Drug Conjugate Targeting a Tumor-Selective EGFR Epitope. Mol Cancer Ther. 2016 Apr;15(4):661-9.  [Content Brief]