2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. LY456066

LY456066 是一种选择性非竞争性代谢型谷氨酸受体 (mGluR1) 拮抗剂，其 IC50 值为 52.0 nM。LY456066 在啮齿模型中有焦虑和疼痛的作用。LY456066 减少了超敏痛和在福尔马林注射后舔舐和抽搐的次数，有望用于慢性疼痛的镇痛剂的研究。

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LY456066 Chemical Structure

LY456066 Chemical Structure

CAS No. : 338738-66-2

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规格 价格 是否有货 数量
1 mg ￥1600
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LY456066 相关抗体

Top Publications Citing Use of Products

查看 mGluR 亚型特异性产品:

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LY456066 is a selective non-competitive metabotropic glutamate receptors (mGluR1) antagonist with an IC50 value of 52.0 nM. LY456066 is effective in rodent models of anxiolysis and nociception. LY456066 reduces hyperalgesia and the amount of licking and flinching following formalin injection, which is promising for research of analgesics for chronic pain[1][2].

分子量

341.47

Formula

C19H23N3OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LY456066 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY456066338738-66-2LY 456066LY-456066mGluRMetabotropic glutamate receptorsmGluR1rodent modelsanxiolysisnociceptionhyperalgesiaanalgesics for chronic painInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-119097
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