2. Academic Validation
  3. Synthesis of 1-(3',4',5'-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent

Synthesis of 1-(3',4',5'-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent

  • Bioorg Med Chem Lett. 2006 Feb 15;16(4):911-4. doi: 10.1016/j.bmcl.2005.10.105.
Vandana Srivastava 1,  Arvind S Negi,  J K Kumar,  Uzma Faridi,  Brijesh S Sisodia,  M P Darokar,  Suaib Luqman,  S P S Khanuja
Affiliations

Affiliation

  • 1 Central Institute of Medicinal and Aromatic Plants (CIMAP), PO CIMAP, Kukrail Road, Lucknow 226 015, India.
PMID: 16297622 DOI: 10.1016/j.bmcl.2005.10.105
Abstract

3',4',5'-Trimethoxy benzoyl-naphthalene 2-O-acetic acid (5) underwent base catalysed intramolecular condensation to yield exclusively 1-(3',4',5'-trimethoxy) phenyl naphtho[2,1-b]furan 8. The cyclised product 8 has been characterised by spectroscopy. The product 8 showed significant Anticancer activity against human Cancer cell lines COLO320DM (colon), CaCO2 (colon) and WRL68 (liver) at 0.7, 0.65 and 0.50 microg/ml concentrations, respectively, in the in vitro MTT assay.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z