2. Academic Validation
  3. Pregnane, coumarin and lupane derivatives and cytotoxic constituents from Helicteres angustifolia

Pregnane, coumarin and lupane derivatives and cytotoxic constituents from Helicteres angustifolia

  • Phytochemistry. 2006 May;67(10):1041-7. doi: 10.1016/j.phytochem.2006.03.005.
Wenliang Chen 1,  Weidong Tang,  Liguang Lou,  Weimin Zhao
Affiliations

Affiliation

  • 1 Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Department of Natural Products Chemistry, 555 Zuchongzhi Road, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
PMID: 16631831 DOI: 10.1016/j.phytochem.2006.03.005
Abstract

2alpha,7beta,20alpha-Trihydroxy-3beta,21-dimethoxy-5-pregnene (1), 6,7,9alpha-trihydroxy-3,8,11alpha-trimethylcyclohexo-[d,e]-coumarin (2), 3beta-hydroxy-27-benzoyloxylup-20(29)-en-28-oic acid (3), and 3beta-hydroxy-27-benzoyloxylup-20(29)-en-28-oic acid methyl ester (4), along with 24 known compounds were isolated and structurally characterized from roots and aerial parts of Helicteres angustifolia (Sterculiaceae). In a preliminary bioassay, the two cucurbitacin derivatives, cucurbitacin D and J exhibited significant inhibitory activities against the growth of both hepatocellular carcinoma BEL-7402 cells and malignant melanoma SK-MEL-28 cells in vitro.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z