2. Academic Validation
  3. Antiproliferative limonoids of a Malleastrum sp. from the Madagascar rainforest

Antiproliferative limonoids of a Malleastrum sp. from the Madagascar rainforest

  • J Nat Prod. 2008 Mar;71(3):325-9. doi: 10.1021/np070487q.
Brian T Murphy 1,  Peggie Brodie,  Carla Slebodnick,  James S Miller,  Chris Birkinshaw,  Lucien M Randrianjanaka,  Rabodo Andriantsiferana,  Vincent E Rasamison,  Karen TenDyke,  Edward M Suh,  David G I Kingston
Affiliations

Affiliation

  • 1 Department of Chemistry, Virginia Polythecnic Institute, Blasburg, Virginia, USA.
PMID: 18177014 DOI: 10.1021/np070487q
Abstract

Bioassay-guided fractionation of an ethanol extract of a Malleastrum sp. afforded three new limonoids, malleastrones A-C ( 1- 3), respectively. Each limonoid contained a rare tetranortriterpenoid skeleton. Structure elucidation of the isolates was carried out by analysis of one- and two-dimensional NMR and X-ray diffraction data. The novel isolates 1 and 2 were tested for antiproliferative activity against a panel of Cancer cell lines and exhibited IC 50 values ranging from 0.19 to 0.63 microM.

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