2. Academic Validation
  3. Towards a modern definition of vitamin E-evidence for a quinone hypothesis

Towards a modern definition of vitamin E-evidence for a quinone hypothesis

  • Bioorg Med Chem Lett. 2012 Jan 1;22(1):391-5. doi: 10.1016/j.bmcl.2011.10.117.
William D Shrader 1,  Akiko Amagata,  Adam Barnes,  Andrew Hinman,  Orion Jankowski,  Edgar Lee,  Viktoria Kheifets,  Ryo Komatsuzaki,  Paul Mollard,  Katsuyuki Murase,  Patrice Rioux,  Kieron Wesson,  Guy Miller
Affiliations

Affiliation

  • 1 Edison Pharmaceuticals, Inc., 350 North Bernardo Avenue, Mountain View, CA 94043, USA. bshrader@edisonpharma.com
PMID: 22137789 DOI: 10.1016/j.bmcl.2011.10.117
Abstract

We report on the synthesis, biological and pharmacological activity of the tocoquinone natural product, α-tocopherol quinone (ATQ); an oxidative metabolite of α-tocopherol. ATQ is a potent cellular protectant against oxidative stress, whose biological activity is dependent upon its ability to undergo reversible two-electron redox cycling. ATQ is orally bioavailable, with a favorable pharmacokinetic profile and has demonstrated a beneficial clinical response in patients with Friedreich's ataxia. ATQ is a member of a broader class of vitamin E derived quinone metabolites which may be ascribable in whole or in part to the activity of vitamin E.

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