2. Academic Validation
  3. Bioactive Maleic Anhydrides and Related Diacids from the Aquatic Hyphomycete Tricladium castaneicola

Bioactive Maleic Anhydrides and Related Diacids from the Aquatic Hyphomycete Tricladium castaneicola

  • J Nat Prod. 2015 Apr 24;78(4):639-44. doi: 10.1021/np500773s.
Chunguang Han 1,  Hiroyuki Furukawa 2,  Tomohiko Tomura 2,  Ryosuke Fudou,  Kenichi Kaida 3,  Bong-Keun Choi 4,  Genji Imokawa 5,  Makoto Ojika 2
Affiliations

Affiliations

  • 1 †Research Center for Materials Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan.
  • 2 ‡Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan.
  • 3 ⊥Institute for Innovation, Ajinomoto Co., Inc., Kawasaki, Kanagawa 210-8681, Japan.
  • 4 ∥Center for Nutraceutical and Pharmaceutical Materials, Myongji University, Cheoin-gu, Yongin, Gyeonggi-Do 449-728, Korea.
  • 5 #Research Institute for Biological Functions, Chubu University, Kasugai 487-8501, Japan.
PMID: 25875311 DOI: 10.1021/np500773s
Abstract

Four maleic anhydride derivatives, tricladolides A-D (1-4), and three alkylidene succinic acid derivatives, tricladic acids A-C (5-7), were isolated from the aquatic hyphomycete Tricladium castaneicola. The structures of these compounds were determined by spectroscopic analysis, and all were found to be novel. The compounds exhibited inhibitory activity against fungi, particularly Phytophthora sp., a plant pathogen of oomycetes. The inhibitory activity of these metabolites revealed the importance of the cyclic anhydride structure and the lipophilicity of the alkyl side chain. On the Other hand, the cytotoxicity of the compounds against B16 melanoma cells indicated that the cyclic anhydride structure was not essential.

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