2. Academic Validation
  3. Mass production of poly(ethylene glycol) monooleate-modified core-shell structured upconversion nanoparticles for bio-imaging and photodynamic therapy

Mass production of poly(ethylene glycol) monooleate-modified core-shell structured upconversion nanoparticles for bio-imaging and photodynamic therapy

  • Sci Rep. 2019 Mar 26;9(1):5212. doi: 10.1038/s41598-019-41482-w.
Xingyuan Zhang 1 2,  Zhao Guo 2 3,  Xiao Zhang 4,  Linji Gong 2 3,  Xinghua Dong 3,  Yanyan Fu 5,  Qing Wang 6 7,  Zhanjun Gu 2 3
Affiliations

Affiliations

  • 1 Institute of Nano Engineering, College of Civil Engineering and Architecture, Shandong University of Science and Technology, Qingdao, 266590, China.
  • 2 Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
  • 3 University of Chinese Academy of Sciences, Beijing, 100049, China.
  • 4 Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China. zhangx89@ihep.ac.cn.
  • 5 State Key Lab of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, 200050, China. fuyy@mail.sim.ac.cn.
  • 6 Institute of Nano Engineering, College of Civil Engineering and Architecture, Shandong University of Science and Technology, Qingdao, 266590, China. profqwang@163.com.
  • 7 School of Material Science and Engineering, Shandong University of Science and Technology, Qingdao, 266590, China. profqwang@163.com.
PMID: 30914696 DOI: 10.1038/s41598-019-41482-w
Abstract

Developing robust and high-efficient synthesis approaches has significant importance for the expanded applications of upconversion nanoparticles (UCNPs). Here, we report a high-throughput synthesis strategy to fabricate water-dispersible core-shell structured UCNPs. Firstly, we successfully obtain more than 10 grams core UCNPs with high quality from one-pot reaction using liquid rare-earth precursors. Afterwards, different core-shell structured UCNPs are fabricated by successive layer-by-layer strategy to get enhanced fluorescence property. Finally, the hydrophobic UCNPs are modified with poly(ethylene glycol) monooleate (PEG-OA) though a novel physical grinding method. On the basis of mass-production, we use the as-prepared PEG-UCNPs to construct an 808-nm stimuli photodynamic therapy agent, and apply them in Cancer therapy and bio-imaging.

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