2. Academic Validation
  3. Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish

Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish

  • Molecules. 2020 Jun 30;25(13):2998. doi: 10.3390/molecules25132998.
Franco Viscarra 1,  Juan González-Gutierrez 2,  Erica Esparza 1,  Carla Figueroa 1,  Pablo Paillali 1,  Martin Hödar-Salazar 1,  Camilo Cespedes 1,  Gabriel Quiroz 3,  Ramón Sotomayor-Zárate 4,  Miguel Reyes-Parada 5 6,  Isabel Bermúdez 7,  Patricio Iturriaga-Vásquez 1 8
Affiliations

Affiliations

  • 1 Laboratorio de Síntesis Orgánica y Farmacología Molecular, Departamento de Ciencias Químicas y Recursos Naturales, Facultad de Ingeniería y Ciencias, Universidad de la Frontera, Temuco 4811230, Chile.
  • 2 Programa de Doctorado en Química, Facultad de Ciencias, Universidad de Chile, Santiago 7800003, Chile.
  • 3 Programa de Doctorado en Farmacología, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago 8380494, Chile.
  • 4 Laboratorio de Neuroquímica y Neurofarmacología, Centro de Neurobiología y Fisiopatología Integrativa (CENFI), Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2360102, Chile.
  • 5 Centro de Investigación Biomédica y Aplicada (CIBAP), Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago 9170022, Chile.
  • 6 Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca 3467987 Chile.
  • 7 Department of Biological & Medical Sciences, Faculty of Health & Life Sciences, Oxford Brookes University, Oxford OX3 0BP, UK.
  • 8 Center of Excellence in Biotechnology Research Applied to the Environment, Universidad de La Frontera, Temuco 4811230, Chile.
PMID: 32630020 DOI: 10.3390/molecules25132998
Abstract

Zebrafish is becoming a popular animal model in neuropharmacology and drug discovery, mainly due to its ease of handling and low costs involved in maintenance and experimental work. This animal displays a series of complex behaviours that makes it useful for assessing the effects of psychoactive drugs. Here, adult zebrafish were used for assessment of the anxiolytic and anti-addictive properties of UFR2709, a nicotinic receptor (nAChR) antagonist, using two behavioural paradigms to test for addiction, the novel tank diving test to assess anxiety and the conditioned place preference (CPP). Furthermore, the expression of nAChR subunits α4 and α7 was measured in the zebrafish brain. The results show that UFR2709 exhibits an anxiolytic effect on zebrafish and blocks the effect evoked by nicotine on CPP. Moreover, UFR2709 significantly decreased the expression of α4 nicotinic receptor subunit. This indicates that UFR2709 might be a useful drug for the treatment of nicotine addiction.

Keywords

anxiety; conditioned place preference (CPP); nicotinic receptor; novel tank test (NTT); reward; zebrafish.

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