2. Academic Validation
  3. Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives

Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives

  • Front Pharmacol. 2020 Sep 15;11:572870. doi: 10.3389/fphar.2020.572870.
Chandan Sarkar 1,  Milon Mondal 1,  Muhammad Torequl Islam 2 3,  Miquel Martorell 4 5,  Anca Oana Docea 6,  Alfred Maroyi 7,  Javad Sharifi-Rad 8,  Daniela Calina 9
Affiliations

Affiliations

  • 1 Department of Pharmacy, Life Science School, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj (Dhaka), Bangladesh.
  • 2 Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
  • 3 Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
  • 4 Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, Chile.
  • 5 Universidad de Concepción, Unidad de Desarrollo Tecnológico, UDT, Concepción, Chile.
  • 6 Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
  • 7 Department of Botany, University of Fort Hare, Alice, South Africa.
  • 8 Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • 9 Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
PMID: 33041814 DOI: 10.3389/fphar.2020.572870
Abstract

The COVID-19 pandemic represents an unprecedented challenge for the researchers to offer safe, tolerable, and effective treatment strategies for its causative agent known as SARS-CoV-2. With the rapid evolution of the pandemic, even the off-label use of existing drugs has been restricted by limited availability. Several old antivirals, antimalarial, and biological drugs are being reconsidered as possible therapies. The effectiveness of the controversial treatment options for COVID-19 such as nonsteroidal antiinflammatory drugs, angiotensin 2 conversion Enzyme inhibitors and selective Angiotensin Receptor blockers was also discussed. A systemic search in the PubMed, Science Direct, LitCovid, Chinese Clinical Trial Registry, and ClinicalTrials.gov data bases was conducted using the keywords "coronavirus drug therapy," passive immunotherapy for COVID-19', "convalescent plasma therapy," (CPT) "drugs for COVID-19 treatment," "SARS-CoV-2," "COVID-19," "2019-nCoV," "coronavirus immunology," "microbiology," "virology," and individual drug names. Systematic reviews, case presentations and very recent clinical guidelines were included. This narrative review summarizes the available information on possible therapies for COVID-19, providing recent data to health professionals.

Keywords

COVID-19 proposed therapy; Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2); convalescent plasma; pandemic; therapeutic challenges.

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