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  3. Emerging Theranostic Nanomaterials in Diabetes and Its Complications

Emerging Theranostic Nanomaterials in Diabetes and Its Complications

  • Adv Sci (Weinh). 2022 Jan;9(3):e2102466. doi: 10.1002/advs.202102466.
Yuntao Liu 1 2,  Siqi Zeng 2,  Wei Ji 3,  Huan Yao 4,  Lin Lin 1,  Haiying Cui 1,  Hélder A Santos 5 6,  Guoqing Pan 7
Affiliations

Affiliations

  • 1 School of Food & Biological Engineering, Jiangsu University, Zhenjiang, 212013, China.
  • 2 College of Food Science, Sichuan Agricultural University, Yaan, 625014, China.
  • 3 Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu, 212013, China.
  • 4 Sichuan Institute of Food Inspection, Chengdu, 610097, China.
  • 5 Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.
  • 6 Department of Biomedical Engineering and W.J. Kolff Institute for Biomedical Engineering and Materials Science, University of Groningen/University Medical Center Groningen, Ant. Deusinglaan 1, Groningen, 9713 AV, The Netherlands.
  • 7 Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang, Jiangsu, 212013, China.
PMID: 34825525 DOI: 10.1002/advs.202102466
Abstract

Diabetes mellitus (DM) refers to a group of metabolic disorders that are characterized by hyperglycemia. Oral subcutaneously administered antidiabetic drugs such as Insulin, glipalamide, and metformin can temporarily balance blood sugar levels, however, long-term administration of these therapies is associated with undesirable side effects on the kidney and liver. In addition, due to overproduction of Reactive Oxygen Species and hyperglycemia-induced macrovascular system damage, diabetics have an increased risk of complications. Fortunately, recent advances in nanomaterials have provided new opportunities for diabetes therapy and diagnosis. This review provides a panoramic overview of the current nanomaterials for the detection of diabetic biomarkers and diabetes treatment. Apart from diabetic sensing mechanisms and antidiabetic activities, the applications of these bioengineered nanoparticles for preventing several diabetic complications are elucidated. This review provides an overall perspective in this field, including current challenges and future trends, which may be helpful in informing the development of novel nanomaterials with new functions and properties for diabetes diagnosis and therapy.

Keywords

acetone sensing; antioxidant; diabetic complications; glucose detection; nanocarrier; wound healing.

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