2. Academic Validation
  3. α-Pyrone and decalin derivatives from the marine-derived fungus Trichoderma harzianum PSU-MF79

α-Pyrone and decalin derivatives from the marine-derived fungus Trichoderma harzianum PSU-MF79

  • Nat Prod Res. 2021 Dec 13;1-8. doi: 10.1080/14786419.2021.2015593.
Sucheewin Nuansri 1,  Vatcharin Rukachaisirikul 1,  Narate Rungwirain 1,  Suchada Kaewin 2,  Chantapol Yimnual 2,  Souwalak Phongpaichit 3,  Sita Preedanon 4,  Jariya Sakayaroj 5,  Chatchai Muanprasat 2
Affiliations

Affiliations

  • 1 Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
  • 2 Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bang Phli, Samut Prakarn, Thailand.
  • 3 Division of Biological Science, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
  • 4 National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani, Thailand.
  • 5 School of Science, Walailak University, Thasala, Nakhonsithammarat, Thailand.
PMID: 34894887 DOI: 10.1080/14786419.2021.2015593
Abstract

Two new compounds, one α-pyrone (trichoharzianone) and one decalin (trichoharzianin), along with eight known compounds including three decalins, two δ-lactones, two carboxylic acids and one isochroman were isolated from the marine-derived fungus Trichoderma harzianum PSU-MF79. The structures were determined by spectroscopic methods. The relative configuration of trichoharzianin was assigned based on NOEDIFF data and coupling constants whereas the absolute configurations were established by comparison of electronic circular dichroism data with those of the co-metabolites. Known (-)-massoia lactone exhibited mild Antifungal activity against Cryptococcus neoformans ATCC90113 flucytosine-resistant, Candida albicans ATCC90028 and C. albicans NCPF3153 with MIC values of 128, 200 and 200 µg/mL, respectively, and weak cytotoxic activity against HCT-116 and MCF-7 cell lines with the respective IC50 values of 17 and 32 µM. In addition, it was noncytotoxic against noncancerous Vero cells with an IC50 value of >100 µM.

Keywords

Trichoderma harzianum; antifungal activity; cytotoxic activity; decalin; marine-derived fungus; α-pyrone; δ-lactone.

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