2. Academic Validation
  3. Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland

Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland

  • Nat Aging. 2024 Mar;4(3):396-413. doi: 10.1038/s43587-024-00588-1.
Qiaoran Wang # 1 2,  Xuebao Wang # 2 3 4 5 6,  Beibei Liu # 1,  Shuai Ma # 4 5 6 7,  Feng Zhang # 8 9,  Shuhui Sun 4 5 6 7,  Yaobin Jing 4 10,  Yanling Fan 1,  Yingjie Ding 1 2,  Muzhao Xiong 1 2,  Jiaming Li 1 2,  Qiaocheng Zhai 8 9,  Yandong Zheng 2 3 4 5 6,  Chengyu Liu 2 3 4 5 6,  Gang Xu 11 12,  Jiayin Yang 11 12,  Si Wang 13 14 15 16,  Jinlin Ye 9,  Juan Carlos Izpisua Belmonte 17,  Jing Qu 18 19 20 21 22 23,  Guang-Hui Liu 24 25 26 27 28 29 30 31 32,  Weiqi Zhang 33 34 35 36
Affiliations

Affiliations

  • 1 CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China.
  • 2 University of Chinese Academy of Sciences, Beijing, China.
  • 3 State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
  • 4 Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
  • 5 Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
  • 6 Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.
  • 7 State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
  • 8 Division of Endocrinology, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, China.
  • 9 The Joint Innovation Center for Engineering in Medicine, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, China.
  • 10 International Center for Aging and Cancer, Hainan Medical University, Haikou, China.
  • 11 Liver Transplant Center, Organ Transplant Center, West China Hospital of Sichuan University, Chengdu, China.
  • 12 Laboratory of Liver Transplantation, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital of Sichuan University, Chengdu, China.
  • 13 Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • 14 Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, China.
  • 15 The Fifth People's Hospital of Chongqing, Chongqing, China.
  • 16 Aging Biomarker Consortium, Beijing, China.
  • 17 Altos Labs, San Diego, CA, USA.
  • 18 University of Chinese Academy of Sciences, Beijing, China. qujing@ioz.ac.cn.
  • 19 State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. qujing@ioz.ac.cn.
  • 20 Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. qujing@ioz.ac.cn.
  • 21 Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. qujing@ioz.ac.cn.
  • 22 Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. qujing@ioz.ac.cn.
  • 23 Aging Biomarker Consortium, Beijing, China. qujing@ioz.ac.cn.
  • 24 University of Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.
  • 25 Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.
  • 26 Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.
  • 27 Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. ghliu@ioz.ac.cn.
  • 28 State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.
  • 29 International Center for Aging and Cancer, Hainan Medical University, Haikou, China. ghliu@ioz.ac.cn.
  • 30 Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing, China. ghliu@ioz.ac.cn.
  • 31 Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, China. ghliu@ioz.ac.cn.
  • 32 Aging Biomarker Consortium, Beijing, China. ghliu@ioz.ac.cn.
  • 33 CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China. zhangwq@big.ac.cn.
  • 34 University of Chinese Academy of Sciences, Beijing, China. zhangwq@big.ac.cn.
  • 35 Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. zhangwq@big.ac.cn.
  • 36 Aging Biomarker Consortium, Beijing, China. zhangwq@big.ac.cn.
  • # Contributed equally.
PMID: 38503993 DOI: 10.1038/s43587-024-00588-1
Abstract

Adrenal glands, vital for steroid secretion and the regulation of metabolism, stress responses and immune activation, experience age-related decline, impacting systemic health. However, the regulatory mechanisms underlying adrenal aging remain largely uninvestigated. Here we established a single-nucleus transcriptomic atlas of both young and aged primate suprarenal glands, identifying lipid metabolism and steroidogenic pathways as core processes impacted by aging. We found dysregulation in centripetal adrenocortical differentiation in aged adrenal tissues and cells in the zona reticularis region, responsible for producing dehydroepiandrosterone sulfate (DHEA-S), were highly susceptible to aging, reflected by senescence, exhaustion and disturbed hormone production. Remarkably, LDLR was downregulated in all cell types of the outer cortex, and its targeted inactivation in human adrenal cells compromised Cholesterol uptake and secretion of dehydroepiandrosterone sulfate, as observed in aged primate adrenal glands. Our study provides crucial insights into endocrine physiology, holding therapeutic promise for addressing aging-related adrenal insufficiency and delaying systemic aging.

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