1. Academic Validation
  2. Current status and progress of research on the ADP-dependent glucokinase gene

Current status and progress of research on the ADP-dependent glucokinase gene

  • Front Oncol. 2024 Mar 25:14:1358904. doi: 10.3389/fonc.2024.1358904.
Ningjing Guo 1 Qiong Luo 1 Qixian Zheng 2 Sheng Yang 1 Suyun Zhang 3
Affiliations

Affiliations

  • 1 Department of Oncology Medicine, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
  • 2 Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
  • 3 Department of Internal Medicine, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Abstract

ADP-dependent Glucokinase (ADPGK) produces glucose-6-phosphate with adenosine diphosphate (ADP) as the phosphate group donor, in contrast to ATP-dependent hexokinases (HKs). Originally found in archaea, ADPGK is involved in glycolysis. However, its biological function in most eukaryotic organisms is still unclear, and the molecular mechanism of action requires further investigation. This paper provides a concise overview of ADPGK's origin, biological function and clinical application. It aims to furnish scientific information for the diagnosis and treatment of human metabolic diseases, neurological disorders, and malignant tumours, and to suggest new strategies for the development of targeted drugs.

Keywords

ADP-dependent glucokinase; glycolysis; immunotherapy; malignant tumours; targeted therapy.

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