Engineering programmable material-to-cell pathways via synthetic notch receptors to spatially control differentiation in multicellular constructs

Affiliations

• 1 Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
• 2 Eli and Edythe Broad Center, University of Southern California, Los Angeles, CA, 90033, USA.
• 3 Alfred E. Mann Department of Biomedical Engineering, USC Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
• 4 Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, USA.
• 5 Utrecht University in the lab of Prof. Dr. Lukas Kapitein, Los Angeles, CA, 90024, USA.
• 6 Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
• 7 Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA, 90024, USA.
• 8 Broad Stem Cell Center, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
• 9 Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
• 10 Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA. mlmccain@usc.edu.
• 11 Alfred E. Mann Department of Biomedical Engineering, USC Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA. mlmccain@usc.edu.
• 12 Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA. morsut@usc.edu.
• 13 Eli and Edythe Broad Center, University of Southern California, Los Angeles, CA, 90033, USA. morsut@usc.edu.
• 14 Alfred E. Mann Department of Biomedical Engineering, USC Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA. morsut@usc.edu.
• # Contributed equally.