2. Academic Validation
  3. Feedforward inhibition of stress by brainstem neuropeptide Y neurons

Feedforward inhibition of stress by brainstem neuropeptide Y neurons

  • Nat Commun. 2024 Sep 1;15(1):7603. doi: 10.1038/s41467-024-51956-9.
Yan Zhang # 1 2 3,  Jiayi Shen # 4,  Famin Xie 1,  Zhiwei Liu 4,  Fangfang Yin 5,  Mingxiu Cheng 6 7,  Liang Wang 4,  Meiting Cai 3,  Herbert Herzog 8 9,  Ping Wu 5,  Zhi Zhang 10,  Cheng Zhan 11 12,  Tiemin Liu 13 14 15 16 17
Affiliations

Affiliations

  • 1 State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
  • 2 Human Phenome Institute, Fudan University, Shanghai, China.
  • 3 Hefei National Research center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China.
  • 4 Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
  • 5 Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China.
  • 6 National Institute of Biological Sciences, Beijing, China.
  • 7 Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China.
  • 8 St Vincent's Centre for Applied Medical Research, Faculty of Medicine, UNSW, Sydney, NSW, Australia.
  • 9 Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
  • 10 State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China. z_zhang@fudan.edu.cn.
  • 11 Hefei National Research center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China. zhancheng@ustc.edu.cn.
  • 12 Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. zhancheng@ustc.edu.cn.
  • 13 State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China. tiemin_liu@fudan.edu.cn.
  • 14 Human Phenome Institute, Fudan University, Shanghai, China. tiemin_liu@fudan.edu.cn.
  • 15 Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism & Integrative Biology, Fudan University, Shanghai, China. tiemin_liu@fudan.edu.cn.
  • 16 Department of Endocrinology and Metabolism, Zhongshan Hospital, Shanghai, China. tiemin_liu@fudan.edu.cn.
  • 17 School of Life Sciences, Inner Mongolia University, Hohhot, China. tiemin_liu@fudan.edu.cn.
  • # Contributed equally.
PMID: 39217143 DOI: 10.1038/s41467-024-51956-9
Abstract

Resistance to stress is a key determinant for mammalian functioning. While many studies have revealed neural circuits and substrates responsible for initiating and mediating stress responses, little is known about how the brain resists to stress and prevents overreactions. Here, we identified a previously uncharacterized neuropeptide Y (NPY) neuronal population in the dorsal raphe nucleus and ventrolateral periaqueductal gray region (DRN/vlPAG) with anxiolytic effects in male mice. NPYDRN/vlPAG neurons are rapidly activated by various stressful stimuli. Inhibiting these neurons exacerbated hypophagic and anxiety responses during stress, while activation significantly ameliorates acute stress-induced hypophagia and anxiety levels and transmits positive valence. Furthermore, NPYDRN/vlPAG neurons exert differential but synergic anxiolytic effects via inhibitory projections to the paraventricular thalamic nucleus (PVT) and the lateral hypothalamic area (LH). Together, our findings reveal a feedforward inhibition neural mechanism underlying stress resistance and suggest NPYDRN/vlPAG neurons as a potential therapeutic target for stress-related disorders.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z