2. Academic Validation
  3. Toxic properties of Beauveria pigments on erythrocyte membranes

Toxic properties of Beauveria pigments on erythrocyte membranes

  • Toxicon. 1997 Aug;35(8):1351-6. doi: 10.1016/s0041-0101(97)00025-1.
L B Jeffs 1,  G G Khachatourians
Affiliations

Affiliation

  • 1 Department of Applied Microbiology and Food Science, University of Saskatchewan, Saskatoon, Canada.
PMID: 9278984 DOI: 10.1016/s0041-0101(97)00025-1
Abstract

The Beauveria Pigments, tenellin, bassianin and oosporein, all inhibited total erythrocyte membrane ATPase activity in a dose-dependent manner by as much as 50% at 200 micrograms/ml. These Pigments inhibited CA(2+)-ATPases to a greater extent than Na+/K(+)-ATPase activity. The ATPase inhibitory activity for these Pigments was not specific but was probably a consequence of membrane disruption, since Pigments all caused alterations in erythrocyte morphology and promoted varying degrees of Cell Lysis.

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