2. Academic Validation
  3. Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides

Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides

  • J Nat Prod. 1998 Sep;61(9):1075-7. doi: 10.1021/np980321c.
G G Harrigan 1,  H Luesch,  W Y Yoshida,  R E Moore,  D G Nagle,  V J Paul,  S L Mooberry,  T H Corbett,  F A Valeriote
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA.
PMID: 9748368 DOI: 10.1021/np980321c
Abstract

A new solid tumor selective cytotoxic analogue of dolastatin 10 (1) has been isolated from the marine cyanobacterium Symploca hydnoides, collected near Guam. This metabolite has been assigned the trivial name symplostatin 1 (2). This discovery supports the proposal that many compounds isolated from the seahare Dolabella auricularia, the original source of the dolastatins, are of dietary origin.

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