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Methyl betulonate  (Synonyms: Betulonic acid methyl ester; Methyl 3-oxolup-20(29)-en-28-oate)

目录号: HY-W773183
Data Sheet 产品使用指南 技术支持

Methyl betulonate (Betulonic acid methyl ester) 是一种三萜系化合物。Methyl betulonate 抑制 8 种肿瘤(包括耐药)和 2 种正常成纤维细胞系的细胞生长,IC50s 值 >50.0 μM。

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Methyl betulonate Chemical Structure

Methyl betulonate Chemical Structure

CAS No. : 4356-31-4

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规格 价格 是否有货 数量
5 mg ¥2672
3 - 4 周
10 mg ¥4280
3 - 4 周
50 mg   询价  
100 mg   询价  

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Methyl betulonate (Betulonic acid methyl ester) is a triterpenoid. Methyl betulonate inhibits cell growth of eight tumor (including resistant) and two normal fibroblast cell lines with the IC50s >50.0 μM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
518A2 IC50
68.05 μM
Compound: 14
Cytotoxicity against human 518A2 cells assessed as cell viability after 96 hrs by SRB assay
Cytotoxicity against human 518A2 cells assessed as cell viability after 96 hrs by SRB assay
[PMID: 23973824]
8505C IC50
> 100 μM
Compound: 14
Cytotoxicity against human 8505C cells assessed as cell viability after 96 hrs by SRB assay
Cytotoxicity against human 8505C cells assessed as cell viability after 96 hrs by SRB assay
[PMID: 23973824]
A2780 IC50
36.25 μM
Compound: 14
Cytotoxicity against human A2780 cells assessed as cell viability after 96 hrs by SRB assay
Cytotoxicity against human A2780 cells assessed as cell viability after 96 hrs by SRB assay
[PMID: 23973824]
A549 IC50
> 100 μM
Compound: 14
Cytotoxicity against human A549 cells assessed as cell viability after 96 hrs by SRB assay
Cytotoxicity against human A549 cells assessed as cell viability after 96 hrs by SRB assay
[PMID: 23973824]
BXPC-3 GI50
2.4 μg/mL
Compound: 24
Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay
Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay
[PMID: 24694263]
CCRF-CEM IC50
250 μM
Compound: 1c
Cytotoxicity against human CEM cells after 72 hrs by MTT assay
Cytotoxicity against human CEM cells after 72 hrs by MTT assay
[PMID: 17371067]
CCRF-CEM IC50
250 μM
Compound: 8
Cytotoxicity against human CEM cells after 72 hrs by MTT assay
Cytotoxicity against human CEM cells after 72 hrs by MTT assay
[PMID: 15270560]
DU-145 GI50
2.3 μg/mL
Compound: 24
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
[PMID: 24694263]
HepG2 CC50
> 400 μM
Compound: 5b
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 29326018]
HT-29 IC50
250 μM
Compound: 8
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
[PMID: 15270560]
K562 IC50
239 μM
Compound: 8
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
[PMID: 15270560]
K562 IC50
250 μM
Compound: 8
Cytotoxicity against paclitaxel-resistant human K562 cells after 72 hrs by MTT assay
Cytotoxicity against paclitaxel-resistant human K562 cells after 72 hrs by MTT assay
[PMID: 15270560]
KM-20L2 GI50
2.2 μg/mL
Compound: 24
Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay
Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay
[PMID: 24694263]
MCF7 GI50
2.7 μg/mL
Compound: 24
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
[PMID: 24694263]
MCF7 IC50
98.1 μM
Compound: 14
Cytotoxicity against human MCF7 cells assessed as cell viability after 96 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as cell viability after 96 hrs by SRB assay
[PMID: 23973824]
NCI-H460 GI50
2.3 μg/mL
Compound: 24
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
[PMID: 24694263]
P388 ED50
> 10 μg/mL
Compound: 24
Cytotoxicity against mouse P388 cells after 48 hrs
Cytotoxicity against mouse P388 cells after 48 hrs
[PMID: 24694263]
PC-3 IC50
250 μM
Compound: 8
Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
[PMID: 15270560]
SF-268 GI50
2.7 μg/mL
Compound: 24
Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
[PMID: 24694263]
Vero CC50
> 400 μM
Compound: 5b
Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
[PMID: 29326018]
分子量

468.71

Formula

C31H48O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
Methyl betulonate
目录号:
HY-W773183
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