2. PROTAC JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. PROTACs EGFR
  4. MS154N

MS154N (compound 28) 是 MS39 (HY-157581) 的阴性对照。MS154N由 PROTAC 靶蛋白配体 EGFR ligand-11 (HY-168305) (red part)、E3 连接酶配体 4-Hydroxy-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione (HY-W441376) (blue part)和8-Iodooctan-1-amine (HY-168306) (black part)组成，其中 E3 泛素连接酶配体+Linker 的偶联物为 Me-Thalidomide-O-C8-NH2 (HY-168307)。

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MS154N Chemical Structure

MS154N Chemical Structure

CAS No. : 2675490-97-6

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规格 价格 是否有货 数量
1 mg ￥6800
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MS154N 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MS154N (compound 28) is the negative control of MS39 (HY-157581). MS154N is composed of PROTAC target protein ligand EGFR ligand-11 (HY-168305) (red part), E3 ligase ligand 4-Hydroxy-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione (HY-W441376) (blue part) and PROTAC Linker 8-Iodooctan-1-amine (HY-168306) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is Me-Thalidomide-O-C8-NH2 (HY-168307)[1].

分子量

915.45

Formula

C47H56ClFN8O8
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: 99.30%

COA (281 KB)

产品使用指南 (1538 KB)
参考文献

MS154N 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS154N2675490-97-6PROTACsEGFREpidermal growth factor receptorErbB-1HER1Epidermal Growth Factor ReceptorNSCLCMS39HCC-827H3255Inhibitorinhibitorinhibit

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目录号：
HY-157579
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