2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Drug Metabolite PPAR Cytochrome P450
  4. N-Desmethyl rosiglitazone

N-Desmethyl rosiglitazone  (Synonyms: SB 237216)

目录号: HY-118788
产品使用指南 技术支持

N-Desmethyl rosiglitazone (SB 237216) 是 Rosiglitazone (HY-17386) 的一种代谢产物，通过肝微粒体中细胞色素 P450 酶系统的去甲基化反应生成，具有一定的 PPARγ 激动效应。N-Desmethyl rosiglitazone 可为 Rosiglitazone (HY-17386) 代谢与药物动力学研究提供有力支持。

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N-Desmethyl rosiglitazone Chemical Structure

N-Desmethyl rosiglitazone Chemical Structure

CAS No. : 257892-31-2

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Other Forms of N-Desmethyl rosiglitazone:

N-Desmethyl rosiglitazone 相关抗体

Top Publications Citing Use of Products

查看 PPAR 亚型特异性产品:

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PPARα PPARβ/δ PPARγ PPAR PPARδ

查看 Cytochrome P450 亚型特异性产品:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

N-Desmethyl rosiglitazone (SB 237216) is a metabolite of Rosiglitazone (HY-17386), generated through demethylation by the cytochrome P450 enzyme system in liver microsomes. It retains partial PPARγ agonist activity and supports studies on the metabolism and pharmacokinetics of Rosiglitazone (HY-17386)[1].

分子量

343.40

Formula

C17H17N3O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

N-Desmethyl rosiglitazone 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Desmethyl rosiglitazone257892-31-2SB 237216SB237216SB-237216Drug MetabolitePPARCytochrome P450Peroxisome proliferator-activated receptorsCYPsInhibitorinhibitorinhibit

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