2. GPCR/G Protein Neuronal Signaling Apoptosis Immunology/Inflammation Protein Tyrosine Kinase/RTK
  3. Adrenergic Receptor TNF Receptor Interleukin Related VEGFR
  4. Naphazoline

Naphazoline  (Synonyms: 萘甲唑啉; Naphthazoline)

目录号: HY-111326
产品使用指南

摩尔计算器

Naphazoline (Naphthazoline) 是一种有效的 α- 肾上腺素能受体 (α-adrenergic receptor) 激动剂。Naphazoline 能降低血管通透性和促进血管收缩。Naphazoline 可降低炎症因子 (TNF-α、IL-1β 和 IL-6)、细胞因子 (IFN-γ 和 IL-4)、IgE、GMCSF 和 NGF 的水平。Naphazoline 可用于非细菌性结膜炎的研究。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Naphazoline nitrate 和 Naphazoline hydrochloride 通常具有更好的水溶性和稳定性。

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Naphazoline Chemical Structure

Naphazoline Chemical Structure

CAS No. : 835-31-4

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Naphazoline 的其他形式现货产品:

Customer Review

Other Forms of Naphazoline:

Naphazoline 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

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α adrenergic receptor β adrenergic receptor

查看 TNF Receptor 亚型特异性产品:

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Naphazoline (Naphthazoline) is a potent α-adrenergic receptor agonist. Naphazoline reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline can be used for non-bacterial conjunctivitis research[1][2].

IC50 & Target

IL-1β

 

IL-6

 

IL-4

 

体内研究
(In Vivo)

Naphazoline (0.2 mg/kg, 10 µl per eye; IP, once) reduces histamine or antigen-induced conjunctival vascular hyperpermeability in mice, and reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female wild-type BALB/c mice (4-5 weeks, 18 ± 2 g, n=8/group, allergic conjunctivitis mouse model established using histamine or an antigen (ovalbumin))[1]
Dosage: 0.2 mg/mL, 10 µl per eye
Administration: Intraperitoneal injection (IP), once
Result: Significantly suppressed conjunctival dye leakage in mice with histamine or antigen‑induced conjunctival vascular hyperpermeability. Reduced inflammatory reactions and the levels of IL-1β, IL-6, IFN-γ, and IL-4. Reduced the levels of IgE, GMCSF, NGF and VEGF in antigen-induced conjunctival vascular hyperpermeability mice.
Clinical Trial
分子量

210.27

Formula

C14H14N2
CAS 号
中文名称

萘甲唑啉
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Naphazoline 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Naphazoline835-31-4Naphthazoline萘甲唑啉Adrenergic ReceptorTNF ReceptorInterleukin RelatedVEGFRBeta ReceptorTumor Necrosis Factor ReceptorTNFRILVascular endothelial growth factor receptordecongestiveconjunctivitisvasoconstrictionvascular hyperpermeabilitycytokinesinflammationInhibitorinhibitorinhibit

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