2. Antibody-drug Conjugate/ADC Related Apoptosis
  3. Antibody-Drug Conjugates (ADCs) Apoptosis
  4. Naratuximab emtansine

Naratuximab emtansine  (Synonyms: IMGN529; Debio 1562)

目录号: HY-132260

摩尔计算器

Naratuximab emtansine (IMGN529) 是一种 CD37 靶向 ADC，由人源化的 IgG1 mAb 与微管破坏子 DM1 偶联组成。Naratuximab emtansine 与 CD37 具有高亲和力和特异性，允许 DM1 的 ADC 内化，加工和细胞内释放。由于其破坏微管组装的能力，DM1 随后可诱导细胞周期停滞和细胞凋亡（apoptosis）。

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Naratuximab emtansine Chemical Structure

Naratuximab emtansine Chemical Structure

CAS No. : 1607824-64-5

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Naratuximab emtansine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Naratuximab emtansine (IMGN529) is a CD37-targeted ADC consisting of a humanized IgG1 mAb coupled to the microtubule disruptor DM1. Naratuximab emtansine has high affinity and specificity for CD37, allowing ADC internalization, processing and intracellular release of DM1. Due to its ability to disrupt microtubule assembly, DM1 can subsequently induce cell cycle arrest and apoptosis[1].

体外研究
(In Vitro)

Naratuximab emtansine (IMGN529) (0.125 nM, 24 h) 单独治疗可诱导DLBCL细胞系中半胱氨酸 3/7 的激活，在 rituximab（2 nM）存在的情况下，这种效果明显增强，进一步诱导裂解的 PARP 水平增加[1]。
Naratuximab emtansine（IMGN529）（0-3 ng/mL）对 U-2932 和 SU-DHL-4 细胞系显示出剂量依赖性抗体依赖的细胞介导的细胞毒性（ADCC）活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Naratuximab emtansine 相关抗体:
体内研究
(In Vivo)

Naratuximab emtansine（IMGN529）（10 毫克/公斤，单次注射）单次治疗对 U-2932 肿瘤无活性，当与 rituximab 联合使用时，显著增强了抗肿瘤活性，且在研究过程中没有观察到 U2932 雌性 CB.17-SCID 小鼠有明显的毒性或体重减轻[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Naratuximab emtansine 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Naratuximab emtansine1607824-64-5IMGN529 Debio 1562IMGN 529IMGN-529Debio1562Debio 1562Debio-1562Antibody-Drug Conjugates (ADCs)ApoptosisAntibody-Drug ConjugatesCD37IgG1 mAbDM1apoptosisanti-tumorInhibitorinhibitorinhibit

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