2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. NCC-149

NCC-149 是一种选择性的 HDAC8 抑制剂，可用于神经分化研究。

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NCC-149 Chemical Structure

NCC-149 Chemical Structure

CAS No. : 1316652-41-1

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥3410
In-stock
1 mg ￥1409
In-stock
5 mg ￥3100
In-stock
10 mg ￥4800
In-stock
25 mg 现货 询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

NCC-149 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NCC-149 is a selective HDAC8 inhibitor and can be used for neural differentiation research[1].

IC50 & Target

HDAC8

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
54 μM
Compound: C149
Inhibition of HDAC in human HeLa cells nuclear extracts by fluorometric assay
Inhibition of HDAC in human HeLa cells nuclear extracts by fluorometric assay
[PMID: 23116147]
HH GI50
23 μM
Compound: C149
Growth inhibition of human HH cells incubated for 72 hrs by MTS assay
Growth inhibition of human HH cells incubated for 72 hrs by MTS assay
[PMID: 23116147]
Jurkat GI50
7.6 μM
Compound: C149
Growth inhibition of human Jurkat cells incubated for 72 hrs by MTS assay
Growth inhibition of human Jurkat cells incubated for 72 hrs by MTS assay
[PMID: 23116147]
MT2 GI50
11 μM
Compound: C149
Growth inhibition of human MT2 cells incubated for 72 hrs by MTS assay
Growth inhibition of human MT2 cells incubated for 72 hrs by MTS assay
[PMID: 23116147]
MT4 GI50
15 μM
Compound: C149
Growth inhibition of human MT4 cells incubated for 72 hrs by MTS assay
Growth inhibition of human MT4 cells incubated for 72 hrs by MTS assay
[PMID: 23116147]
NB1 GI50
12 μM
Compound: C149
Growth inhibition of human NB-1 cells incubated for 72 hrs by MTS assay
Growth inhibition of human NB-1 cells incubated for 72 hrs by MTS assay
[PMID: 23116147]
PBMC GI50
> 100 μM
Compound: C149
Growth inhibition of human PBMC PB-N cells incubated for 72 hrs by MTS assay
Growth inhibition of human PBMC PB-N cells incubated for 72 hrs by MTS assay
[PMID: 23116147]
PBMC GI50
> 100 μM
Compound: C149
Growth inhibition of human PBMC PB-O cells incubated for 72 hrs by MTS assay
Growth inhibition of human PBMC PB-O cells incubated for 72 hrs by MTS assay
[PMID: 23116147]
体外研究
(In Vitro)

NCC-149 (5 μM; 3 days) remarkably reduces NeuN expression levels in P19 cells[1].
NCC-149 (0-40 μM; 4 days) reduces embryoid body size in a dose-dependent manner[1].
NCC-149 (5 and 20 μM; 24 h) downregulates P19 cell proliferation[1].
NCC-149 (2.5 and 5 μM; 24 h) leads to cell growth retardation by G2/M phase arrest[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NCC-149 相关抗体:

Western Blot Analysis[1]

Cell Line: P19 cells
Concentration: 5 μM
Incubation Time: 3 days
Result: Remarkably reduced NeuN expression levels.

Cell Proliferation Assay[1]

Cell Line: P19 cells
Concentration: 5 and 20 μM
Incubation Time: 24 h
Result: Downregulated cell proliferation.

Cell Cycle Analysis[1]

Cell Line: P19 cells
Concentration: 2.5 and 5 μM
Incubation Time: 24 h
Result: Led to a significant increase in G2/M phase cells, with a slight decrease in S phase cells.

RT-PCR[1]

Cell Line: P19 cells
Concentration: 25 μM or 2.5 and 5 μM
Incubation Time: 4 days (25 μM) or 48 h (2.5 and 5 μM)
Result: Did not reduce the HDAC8 expression at the mRNA level.
Significantly and partially reduced cyclin B1 and cyclin A2 gene expression, respectively.
分子量

326.37

Formula

C16H14N4O2S
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (383.00 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0640 mL 15.3200 mL 30.6401 mL
5 mM 0.6128 mL 3.0640 mL 6.1280 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.14%

COA (190 KB) RP-HPLC (244 KB) LCMS (112 KB)

产品使用指南 (1538 KB)
参考文献

NCC-149 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0640 mL 15.3200 mL 30.6401 mL 76.6002 mL
5 mM 0.6128 mL 3.0640 mL 6.1280 mL 15.3200 mL
10 mM 0.3064 mL 1.5320 mL 3.0640 mL 7.6600 mL
15 mM 0.2043 mL 1.0213 mL 2.0427 mL 5.1067 mL
20 mM 0.1532 mL 0.7660 mL 1.5320 mL 3.8300 mL
25 mM 0.1226 mL 0.6128 mL 1.2256 mL 3.0640 mL
30 mM 0.1021 mL 0.5107 mL 1.0213 mL 2.5533 mL
40 mM 0.0766 mL 0.3830 mL 0.7660 mL 1.9150 mL
50 mM 0.0613 mL 0.3064 mL 0.6128 mL 1.5320 mL
60 mM 0.0511 mL 0.2553 mL 0.5107 mL 1.2767 mL
80 mM 0.0383 mL 0.1915 mL 0.3830 mL 0.9575 mL
100 mM 0.0306 mL 0.1532 mL 0.3064 mL 0.7660 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCC-1491316652-41-1NCC149NCC 149HDACHistone deacetylasesembryoid bodyNeuNP19neural differentiationInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-117348
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