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NCT-504 是选择性的脂质激酶 PIP4Kγ 变构抑制剂，其 IC50 值为 15.8 μM。NCT-504 具有用于亨廷顿氏症疾病研究的潜力。

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NCT-504 Chemical Structure

NCT-504 Chemical Structure

CAS No. : 1222765-97-0

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥3520
In-stock
1 mg ￥1280
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5 mg ￥3200
In-stock
10 mg ￥5100
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Customer Review

NCT-504 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NCT-504 is a selective allosteric inhibitor of PIP4Kγ, with an IC50 of 15.8 μM. NCT-504 is potential for the research of Huntington's disease[1].

IC50 & Target

IC50: 15.8 μM (PIP4Kγ)[1]
体外研究
(In Vitro)

NCT-504 dose not impair the intrinsic ATP-hydrolytic activity of PIP4Kγ in the absence of PI5P substrate[1].
NCT-504 does not inhibit PIP4Kbeta and weakly inhibits PIP4Kalpha phosphorylation of PI5P [1].
NCT-504 dose not inhibit PIP4Kbeta or PIP4Kalpha (IC50 between 50 μM and 100 μM) at 50 μM concentration[1].
NCT-504 elevates the levels of PI(3,5)P2, PI3P and PI5P in MEFs[1].
NCT-504 (10 μM; 12 hours) does not affect cell viability in MEFs[1].
NCT-504 (5 μM, 10 μM; 2 hours, 6 hours) elevates both the induction of autophagy as well as the rate of turnover of autophagic cargo[1].
NCT-504 treatment causes a robust increase in the formation of autolysosomes with only a modest elevation in autophagosomes[1].
NCT-504 increases autophagy flux and decreases huntingtin protein in 293A cells[1].
NCT-504 reduces mHtt protein levels in immortalized striatal cells from knock-in HD mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NCT-504 相关抗体:

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 5 μM, 10 μM
Incubation Time: 2 hours, 6 hours
Result: Induced autophagosome formation.
分子量

404.49

Formula

C15H12N6O2S3
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (309.03 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4722 mL 12.3612 mL 24.7225 mL
5 mM 0.4944 mL 2.4722 mL 4.9445 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.70%

COA (272 KB) HNMR (262 KB) LCMS (268 KB)

产品使用指南 (1538 KB)
参考文献

NCT-504 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4722 mL 12.3612 mL 24.7225 mL 61.8062 mL
5 mM 0.4944 mL 2.4722 mL 4.9445 mL 12.3612 mL
10 mM 0.2472 mL 1.2361 mL 2.4722 mL 6.1806 mL
15 mM 0.1648 mL 0.8241 mL 1.6482 mL 4.1204 mL
20 mM 0.1236 mL 0.6181 mL 1.2361 mL 3.0903 mL
25 mM 0.0989 mL 0.4944 mL 0.9889 mL 2.4722 mL
30 mM 0.0824 mL 0.4120 mL 0.8241 mL 2.0602 mL
40 mM 0.0618 mL 0.3090 mL 0.6181 mL 1.5452 mL
50 mM 0.0494 mL 0.2472 mL 0.4944 mL 1.2361 mL
60 mM 0.0412 mL 0.2060 mL 0.4120 mL 1.0301 mL
80 mM 0.0309 mL 0.1545 mL 0.3090 mL 0.7726 mL
100 mM 0.0247 mL 0.1236 mL 0.2472 mL 0.6181 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCT-5041222765-97-0NCT504NCT 504OthersneurodegenerativedisordersHuntington'sdiseasemHttneurodegenerationInhibitorinhibitorinhibit

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目录号：
HY-136311
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