Neuropeptide Y (human) (free acid) 

Neuropeptide Y (human) free acid upregulates the adhesiveness of human endothelial cells for leukocytes. Neuropeptide Y belongs to the pancreatic polypeptide family, plays an important role in circadian rhythms, neurogenesis, and neuroprotection, nociception, feeding behavior, energy regulation, neuronal excitability, emotion, cognition, and stress response^[1][2].

Neuropeptide Y (human) free acid 抑制 SK-N-MC 细胞中 Isoproterenol (HY-B0468), Dopamine, Vasoactive intestinal peptide, Cholera toxin, Forskolin (HY-15371) 诱导的 cyclic AMP 累积^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4272.67

C₁₈₉H₂₈₄N₅₄O₅₈S

99575-89-0

Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr

YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQ

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Cajado et al. Neuropeptide Y family-degrading metallopeptidases in the Tityus serrulatus venom partially blocked by commercial antivenoms. Toxicol Sci. 2014 Dec;142(2):418-26.  [Content Brief]

  [2]. Sung CP, et al. Neuropeptide Y upregulates the adhesiveness of human endothelial cells for leukocytes. Circ Res. 1991 Jan;68(1):314-8.  [Content Brief]

  [3]. Gordon EA, et al. Characterization of functional neuropeptide Y receptors in a human neuroblastoma cell line. J Neurochem. 1990 Aug;55(2):506-13.  [Content Brief]