2. NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Autophagy Apoptosis PI3K/Akt/mTOR Stem Cell/Wnt JAK/STAT Signaling
  3. NF-κB Reactive Oxygen Species Autophagy Apoptosis HIF/HIF Prolyl-Hydroxylase Akt STAT PI3K
  4. NF-κB-IN-19

NF-κB-IN-19 (Compound 8) 是一种 NF-κB 抑制剂。NF-κB-IN-19 通过 NF-κB 信号通路有效诱导肿瘤细胞 DNA 损伤、促进 ROS 生成以及诱导细胞自噬 (autophagy) 和凋亡 (apoptosis)。此外，NF-κB-IN-19 可抑制 VEGF 和 HIF-1α 水平，并通过 PI3K/AKT 和 STAT-3 途径在肿瘤细胞中发挥抗增殖活性。NF-κB-IN-19 能有效克服顺铂耐药性，具有抗肿瘤的活性。

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NF-κB-IN-19 Chemical Structure

NF-κB-IN-19 Chemical Structure

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NF-κB-IN-19 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 HIF/HIF Prolyl-Hydroxylase 亚型特异性产品:

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HIF-1α HIF

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NF-κB-IN-19 (Compound 8) is an NF-κB inhibitor. NF-κB-IN-19 effectively induces DNA damage, promotes the generation of ROS, and induces autophagy and apoptosis through the NF-κB signaling pathway in tumor cells. In addition, NF-κB-IN-19 can inhibit the levels of VEGF and HIF-1α, and exert antiproliferative activity in tumor cells through the PI3K/AKT and STAT-3 pathways. NF-κB-IN-19 can effectively overcome cisplatin resistance and has anti-tumor activity[1].

分子量

759.92

Formula

C24H26Cl3F2N3O4Pt
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NF-κB-IN-19 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NF-κB-IN-19NF-κBReactive Oxygen SpeciesAutophagyApoptosisHIF/HIF Prolyl-HydroxylaseAktSTATPI3KNuclear factor-κBNuclear factor-kappaBHypoxia-inducible factorsHIFsHIF-PHPKBProtein kinase BPhosphoinositide 3-kinaseA549NCI-H460A2780SGC-7901Lung cancer modelInhibitorinhibitorinhibit

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