2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. NSC12

NSC12 是 FGF2 的细胞外陷阱，与 FGF2 结合并干扰其与 FGFR1 的相互作用。NSC12 在体外和体内均能抑制 FGF 依赖性不同肿瘤细胞的增殖，且无全身毒性作用。

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NSC12 Chemical Structure

NSC12 Chemical Structure

CAS No. : 102586-30-1

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规格 价格 是否有货 数量
5 mg ￥1200
In-stock
10 mg ￥2000
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

NSC12 相关抗体

Top Publications Citing Use of Products

查看 FGFR 亚型特异性产品:

查看所有亚型
FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NSC 12 is an extracellular trap of fibroblast growth factor 2 (FGF2) that binds FGF2 and interferes with its interaction with FGFR1. NSC12 inhibits the proliferation of different FGF-dependent tumour cells both in vitro and in vivo with no systemic toxic effects[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO-K1 IC50
10 μM
Compound: 11
Inhibition of human recombinant FGF2 assessed as reduction in HSPG/FGF2/FGDR interaction by measuring FGF2 mediated A475-CHO-flg-1A-luc cell to CHO-K1 cell adhesion incubated for 2 hrs by luciferase assay
Inhibition of human recombinant FGF2 assessed as reduction in HSPG/FGF2/FGDR interaction by measuring FGF2 mediated A475-CHO-flg-1A-luc cell to CHO-K1 cell adhesion incubated for 2 hrs by luciferase assay
[PMID: 27138345]
KMS-11 IC50
3.4 μM
Compound: 1; NSC12
Antiproliferative activity against human KMS-11 cells assessed as reduction in cell viability incubated for 48 hrs by propidium iodide staining-based flow cytometric analysis
Antiproliferative activity against human KMS-11 cells assessed as reduction in cell viability incubated for 48 hrs by propidium iodide staining-based flow cytometric analysis
[PMID: 34004471]
Lewis lung carcinoma cell line IC50
2 μM
Compound: 11
Antiproliferative activity against mouse LLC cells incubated for 48 hrs by PI-staining based flow cytometry
Antiproliferative activity against mouse LLC cells incubated for 48 hrs by PI-staining based flow cytometry
[PMID: 27138345]
NCI-H520 IC50
4.1 μM
Compound: 11
Antiproliferative activity against human NCI-H520 cells incubated for 72 hrs by PI-staining based flow cytometry
Antiproliferative activity against human NCI-H520 cells incubated for 72 hrs by PI-staining based flow cytometry
[PMID: 27138345]
分子量

484.52

Formula

C24H34F6O3
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 10 mg/mL (20.64 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0639 mL 10.3195 mL 20.6390 mL
5 mM 0.4128 mL 2.0639 mL 4.1278 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.07%

COA (172 KB) HNMR (115 KB) RP-HPLC (194 KB)

产品使用指南 (1538 KB)
参考文献

NSC12 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0639 mL 10.3195 mL 20.6390 mL 51.5975 mL
5 mM 0.4128 mL 2.0639 mL 4.1278 mL 10.3195 mL
10 mM 0.2064 mL 1.0319 mL 2.0639 mL 5.1597 mL
15 mM 0.1376 mL 0.6880 mL 1.3759 mL 3.4398 mL
20 mM 0.1032 mL 0.5160 mL 1.0319 mL 2.5799 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC12102586-30-1NSC 12NSC-12FGFRFibroblast growth factor receptorInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-107194
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