2. MAPK/ERK Pathway
  3. p38 MAPK
  4. p38 MAP Kinase Inhibitor IV

p38 MAP Kinase Inhibitor IV 

目录号: HY-112401 纯度: 98.0%
COA 产品使用指南

摩尔计算器

p38 MAP Kinase Inhibitor IV 是一种高度特异的 ATP 竞争性 p38α MAPK 抑制剂，p38 MAP Kinase Inhibitor IV 对 p38α 和 p38β MAPK 的 IC50 分别为 0.13 和 0.55 μM。

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p38 MAP Kinase Inhibitor IV Chemical Structure

p38 MAP Kinase Inhibitor IV Chemical Structure

CAS No. : 1638-41-1

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5 mg ￥1296
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p38 MAP Kinase Inhibitor IV 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

p38 MAP Kinase Inhibitor IV is a highly specific ATP-competitive p38α MAPK inhibitor with IC50s of 0.13 and 0.55 μM for p38α and p38β MAPK, respectively[1].

IC50 & Target

p38α

0.13 μM (IC50)

p38β

0.55 μM (IC50)

p38δ

8.63 μM (IC50)

p38χ

5.47 μM (IC50)

体外研究
(In Vitro)

p38 MAP Kinase Inhibitor IV (MT4) shows IC50 values of 0.13, 0.55, 5.47, and 8.63μM for p38α, β, χ, andδ, respectively. p38 MAP Kinase Inhibitor IV has the suppressive action on the release of TNF-alpha and IL-1beta in PBMC with IC50 values of 22 and 44 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

p38 MAP Kinase Inhibitor IV 相关抗体:
分子量

456.94

Formula

C12H4Cl6O4S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 98.0%

COA (295 KB)

产品使用指南 (1538 KB)
参考文献

p38 MAP Kinase Inhibitor IV 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p38 MAP Kinase Inhibitor IV1638-41-1p38 MAPKTNF-αLPSPBMCanti-inflammatoryATP-competitiveInhibitorinhibitorinhibit

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产品名称：
p38 MAP Kinase Inhibitor IV
目录号：
HY-112401
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