2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. Penpulimab

Penpulimab  (Synonyms: 派安普利单抗)

目录号: HY-P99108 纯度: 98.80%
COA 技术支持

Penpulimab 是一种 IgG1 抗 PD-1 单克隆抗体，具有抗肿瘤活性。

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CAS No. : 2350298-92-7

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5 mg ￥2700
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10 mg ￥4200
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Penpulimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Penpulimab is an IgG1 backbone anti-PD-1 monoclonal antibody with antitumor activities[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Chimeric; Humanized
体外研究
(In Vitro)

Penpulimab demonstrates better stability and a lower level of host-cell protein residue compared with IgG4 backbone anti-PD-1 antibodies[1].
Penpulimab does not mediate complement-dependent cytotoxicity (CDC) or antibody-dependent cell-mediated cytotoxicity (ADCC) and induces no remarkable IL-6 and IL-8 release by activated macrophages[1].
Penpulimab exhibits slower binding off-rate for human PD-1 than Nivolumab (HY-P9903) and Pembrolizumab (HY-P9902)[1].
Penpulimab potentiates T cell activation via PD-1/PD-L1 blockade[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Penpulimab 相关抗体:
体内研究
(In Vivo)

Penpulimab (5 mg/kg; i.p.; twice a week, 3weeks) inhibits tumor growth in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MC38-hPD-L1 tumor-bearing B-hPD-1 humanized mouse model[2]
Dosage: 5 mg/kg
Administration: IP, twice a week, 3weeks
Result: Showed moderate inhibition of tumor growth (tumor volume: 58.4% of control group). Treatment combined with anlotinib (1 mg/kg, every day, p.o) significantly decreased tumor volume to 36.5% of control group.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

派安普利单抗
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献

Penpulimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Penpulimab2350298-92-7派安普利单抗PD-1/PD-L1PD-1/Programmed death-ligand 1gastrointestinal cancershepatocellular carcinomaHCCHodgkin lymphomanon-small-cell lung cancerNSCLCInhibitorinhibitorinhibit

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