2. Apoptosis
  3. Apoptosis
  4. Pheophorbide A

Pheophorbide A 是叶绿素降解途径中的中间产物。Pheophorbide A 可用作光敏剂。Phoophorbide A 是一种淋巴血管激活剂。Pheophorbide A 具有抗肿瘤活性。Phoophorbide A 可用于人体淋巴管功能不全的研究。

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Pheophorbide A Chemical Structure

Pheophorbide A Chemical Structure

CAS No. : 15664-29-6

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规格 价格 是否有货 数量
1 mg ￥340
In-stock
5 mg ￥850
In-stock
10 mg ￥1360
In-stock
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100 mg   询价  

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Customer Review

Pheophorbide A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pheophorbide A is an intermediate product in the chlorophyll degradation pathway. Pheophorbide A can be used as a photosensitizer. Pheophorbide A is a lymphatic vascular activator. Pheophorbide A has antitumor activity. Pheophorbide A can be used for human lymphatic vascular insufficiencies research[1][2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
1A9 ED50
0.48 μg/mL
Compound: 2
Cytotoxicity against human 1A9 cells after 72 hrs by SRB assay
Cytotoxicity against human 1A9 cells after 72 hrs by SRB assay
[PMID: 11473423]
A549 ED50
1.5 μg/mL
Compound: 2
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
[PMID: 11473423]
HCT-8 ED50
1.5 μg/mL
Compound: 2
Cytotoxicity against human HCT8 cells after 72 hrs by SRB assay
Cytotoxicity against human HCT8 cells after 72 hrs by SRB assay
[PMID: 11473423]
KB ED50
0.46 μg/mL
Compound: 2
Cytotoxicity against human KB cells after 72 hrs by SRB assay
Cytotoxicity against human KB cells after 72 hrs by SRB assay
[PMID: 11473423]
MCF7 ED50
1.6 μg/mL
Compound: 2
Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
[PMID: 11473423]
SK-MEL ED50
0.91 μg/mL
Compound: 2
Cytotoxicity against human SK-MEL cells after 72 hrs by SRB assay
Cytotoxicity against human SK-MEL cells after 72 hrs by SRB assay
[PMID: 11473423]
体外研究
(In Vitro)

Pheophorbide A (10 µM) 可促进淋巴内皮细胞 (LEC) 萌芽、增殖和管形成[1]。
Pheophorbide A 介导的光动力疗法 (Pa-PDT) 以剂量依赖性方式抑制 Hep3B 上的细胞生长，IC50 为 1.5 μM[2]。
光激活后 Pheophorbide A (2 µM, 24 h) 可诱导 Hep3B 细胞凋亡[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pheophorbide A 相关抗体:
体内研究
(In Vivo)

Pheophorbide A 光动力疗法 (Pa-PDT) （10 mg/kg（静脉注射）或 30 mg/kg（腹腔注射））可显著抑制皮下注射 AT-84 细胞的 C3H 小鼠模型中的肿瘤生长[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male immunocompetent C3H mouse (six-week-old, inoculated subcutaneously with AT-84 cells)[3]
Dosage: 10 mg/kg intravenous (i.v.) or a 30 mg/kg intraperitoneal (i.p.) injection
Administration: IV or IP; after 24 h, PDT was performed
Result: Pa-PDT, especially i.v. Pa-PDT, significantly inhibited tumor growth up to 70%, while the i.p. Pa-PDT-induced inhibition was up to 43.4% relative to the control group at the end of period.
分子量

592.68

Formula

C35H36N4O5
CAS 号
性状

固体

颜色

Brown to black

结构分类
初始来源

Botrytis cinerea
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 2 mg/mL (3.37 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

Methanol 中的溶解度 : < 1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6873 mL 8.4363 mL 16.8725 mL
5 mM --- --- ---
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 93.6%

COA (297 KB)

产品使用指南 (1538 KB)
参考文献

Pheophorbide A 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6873 mL 8.4363 mL 16.8725 mL 42.1813 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pheophorbide A15664-29-6ApoptosisE. Perfoliatumlymphatic vascular activatorEupatorium perfoliatumPlant extractLymphangiogenesisLymphatic activatorHepatocellular Carcinoma CellsAT-84 cellsInhibitorinhibitorinhibit

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