2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. PI3Kα-IN-5

PI3Kα-IN-5 (compound 6 ab) 是一种有效的 PI3Kα/mTOR 抑制剂，IC50 值分别为 0.7 nM 和 3.3 nM。PI3Kα-IN-5 可用于结直肠癌的研究。

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PI3Kα-IN-5 Chemical Structure

PI3Kα-IN-5 Chemical Structure

CAS No. : 2237953-19-2

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PI3Kα-IN-5 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3Kα-IN-5 (compound 6 ab) is a potent PI3Kα/mTOR inhibitor, with an IC50 of 0.7 nM and 3.3 nM, respectively. PI3Kα-IN-5 can be used for the research of colorectal cancer[1].

IC50 & Target[1]

PI3Kα

0.7 nM (IC50)

mTOR

3.3 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-431 IC50
0.218 μM
Compound: 6ab
Antiproliferative activity against human A431 cells harboring wild type EGFR mutant assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay
Antiproliferative activity against human A431 cells harboring wild type EGFR mutant assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay
[PMID: 34971874]
BaF3 IC50
0.217 μM
Compound: 6ab
Antiproliferative activity against mouse BaF3 cells harboring EGFR L858R/T790M/C797S mutant assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay
Antiproliferative activity against mouse BaF3 cells harboring EGFR L858R/T790M/C797S mutant assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay
[PMID: 34971874]
CNE-2 IC50
0.07 μM
Compound: 6ab
Antiproliferative activity against human CNE-2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human CNE-2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34971874]
HCT-116 IC50
0.11 μM
Compound: 6ab
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34971874]
HeLa IC50
13.44 μM
Compound: 6ab
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34971874]
HepG2 IC50
15.14 μM
Compound: 6ab
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34971874]
L02 IC50
> 100 μM
Compound: 6ab
Antiproliferative activity against human L02 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human L02 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34971874]
MCF7 IC50
2.22 μM
Compound: 6ab
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34971874]
MDA-MB-231 IC50
6.48 μM
Compound: 6ab
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34971874]
NCI-H1975 IC50
0.217 μM
Compound: 6ab
Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M double mutant assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay
Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M double mutant assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay
[PMID: 34971874]
分子量

601.66

Formula

C30H35N9O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3Kα-IN-5 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kα-IN-52237953-19-2PI3KmTORPhosphoinositide 3-kinaseMammalian target of RapamycincolorectalcancerInhibitorinhibitorinhibit

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