2. PI3K/Akt/mTOR
  3. PI3K Akt
  4. PI3Kα-IN-23

PI3Kα-IN-23 (Compound 9) 是 PI3Ka H1047R 的抑制剂。

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PI3Kα-IN-23 Chemical Structure

PI3Kα-IN-23 Chemical Structure

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规格 是否有货
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Customer Review

PI3Kα-IN-23 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3Kα-IN-23 (Compound 9) is an inhibitor of PI3Ka H1047R[1].

IC50 & Target[1]

PI3Kα-H1047R

 

体外研究
(In Vitro)

PI3Kα-IN-23 抑制细胞中 pAKT 磷酸化的能力分别为50=1 nM-500 nM (T-47D); >15 μΜ(SKBR3)[1]。
PI3Kα-IN-23 抑制细胞增殖的能力分别为 EC50=500 nM-2 μΜ (T-47D); 2 μΜ-15 μΜ (SKBR3)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3Kα-IN-23 相关抗体:
体内研究
(In Vivo)


在 PK-Mouse 中的药代动力学分析[1]

Route Dose (mg/kg) Cl (mL/min/kg) AUClast (h·ng/mL) F (%)
i.v. 1 35.7 464 /
p.o. 10 / 1950 41

IV Vehicle: 20% PEG400 / 20% PG / 60% of 20% ΗΡβCD solution in water
PO Vehicle: 30% SBE3CD in water

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

453.53

Formula

C28H27N3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3Kα-IN-23 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kα-IN-23PI3KAktPhosphoinositide 3-kinasePKBProtein kinase BcancerPK-MouseInhibitorinhibitorinhibit

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产品名称：
PI3Kα-IN-23
目录号：
HY-163501
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