2. Cell Cycle/DNA Damage
  3. CDK
  4. (+)-Atuveciclib

(+)-Atuveciclib  (Synonyms: (+)-BAY-1143572)

目录号: HY-12871A
产品使用指南

摩尔计算器

(+)-Atuveciclib 是 Atuveciclib (Racemate) (HY-12871) 的异构体。Atuveciclib Racemate (BAY-1143572 Racemate) 是 Atuveciclib 的外消旋混合物。 Atuveciclib 是一种有效且高选择性的口服 P-TEFb/CDK9 抑制剂，CDK9/CycT1 的IC50 为13 nM。

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(+)-Atuveciclib Chemical Structure

(+)-Atuveciclib Chemical Structure

CAS No. : 1414943-94-4

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Other Forms of (+)-Atuveciclib:

(+)-Atuveciclib 相关抗体

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(+)-Atuveciclib is the isomer of Atuveciclib (Racemate) (HY-12871). Atuveciclib Racemate (BAY-1143572 Racemate) is the racemate mixture of Atuveciclib. Atuveciclib is a potent and highly selective，oral P-TEFb/CDK9 inhibitor which supresses CDK9/CycT1 with an IC50 of 13 nM.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
1500 nM
Compound: 50; BAY-1143572
Antiproliferative activity against human HeLa cells incubated for 96 hrs by crystal violet staining assay
Antiproliferative activity against human HeLa cells incubated for 96 hrs by crystal violet staining assay
[PMID: 32870008]
分子量

387.43

Formula

C18H18FN5O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(+)-Atuveciclib 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-Atuveciclib1414943-94-4(+)-BAY-1143572CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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