2. PROTAC Apoptosis
  3. PROTACs Ferroptosis
  4. PROTAC NCOA4 degrader-1

PROTAC NCOA4 degrader-1 (Compound V3) 是一种基于 PROTAC 的 NCOA4 降解剂 (DC50: HeLa 细胞中为 3 nM)。PROTAC NCOA4 degrader-1 是一种铁死亡 (ferroptosis ) 抑制剂。PROTAC NCOA4 degrader-1 可降低 NCOA4 水平并下调细胞内亚铁 (Fe2+) 水平。PROTAC NCOA4 degrader-1 可改善 CCl4 诱发的急性肝损伤模型中的肝损伤。(红色: NCOA4 配体 (HY-149457)。黑色: linker (HY-163903)。蓝色: VHL 配体 (HY-138678B))。

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PROTAC NCOA4 degrader-1 Chemical Structure

PROTAC NCOA4 degrader-1 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥3850
1 - 3 周
5 mg 现货 1 - 3 周
10 mg 现货 1 - 3 周
50 mg   询价  
100 mg   询价  

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PROTAC NCOA4 degrader-1 相关抗体

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC NCOA4 degrader-1 (Compound V3) is a PROTAC NCOA4 degrader (DC50: 3 nM in HeLa cells). PROTAC NCOA4 degrader-1 is a ferroptosis inhibitor. PROTAC NCOA4 degrader-1 reduces NCOA4 levels and downregulates intracellular ferrous iron (Fe2+) levels. PROTAC NCOA4 degrader-1 ameliorates liver damage in a CCl4-induced acute liver injury model. (Red: NCOA4 ligand (HY-149457). Black: linker (HY-163903). Blue: VHL ligand (HY-138678B))[1].

分子量

1141.43

Formula

C62H80N10O9S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC NCOA4 degrader-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC NCOA4 degrader-1PROTACsFerroptosisacute liver injuryInhibitorinhibitorinhibit

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目录号：
HY-163897
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