IFN-alpha 6  (干扰素 α6)

干扰素 α6 (IFNA6;IFN-α6) 属于 α / β 干扰素 (IFN) 家族，由巨噬细胞产生，具有抗病毒活性^[1]。干扰素 (IFN) 最初被认为是一种“干扰”体外病毒复制的物质。IFN-α/β 及其相关分子被分为I型IFN，及其他两类—— II 型 IFN (IFN-γ) 和 III 型 IFN (IFN-λ)^[2]。干扰素刺激两种酶的产生：一种蛋白激酶和一种低聚腺苷酸合成酶。干扰素 α (IFNa) 在各种癌症中显示出显著的生物活性，特别是血液系统恶性肿瘤，如毛细胞白血病和慢性骨髓性白血病^[3]。I 型干扰素在病毒感染反应早期产生，能够调节适应性免疫。干扰素 α6 参与了急性心肌炎和慢性心脏炎症抑制，通过抑制小鼠巨细胞病毒 (MCMV) 复制改善全身感染小鼠 MCMV的动物模型^[4].

IFN-alpha 6 (IFNA6; IFN-α6), belongs to the alpha/beta interferon (IFN) family, is produced by the macrophages with antiviral activities^[1]. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively^[2]. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia^[3]. Type I interferons (IFNs) are produced early in response to viral infection and modulate adaptive immunity. IFN-alpha 6 involves in acute myocarditis and chronic cardiac inflammation inhibition, promotes systemic murine cytomegalovirus (MCMV) infection by reducing MCMV replication^[4].

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