悬尾实验（TST，Tail Suspension Test）是一种常用于评估小鼠或大鼠抗抑郁效果的实验。在实验中，动物被悬挂在一个高处，使其尾巴悬空。动物为逃避而表现出的无助感被用作测量抗抑郁效果的指标，即动物的运动减少。抗抑郁药物通常能够减少这种无助感表现。TST 常用于药物筛选和研究抗抑郁药物的神经生物学机制，但也需注意其在行为学模型中的局限性。

The Tail Suspension Test (TST) is a test commonly used to evaluate antidepressant effects in mice or rats. In the experiment, the animals were suspended from a high place with their tails in the air. The helplessness displayed by the animal in order to escape was used as a measure of the antidepressant effect, i.e., the animal's reduced movement. Antidepressants often reduce this feeling of helplessness. TST is often used for drug screening and studying the neurobiological mechanisms of antidepressant drugs, but its limitations in behavioral models should also be noted.