2. 重组蛋白
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  4. CSF & Receptors
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  6. CSF1R 蛋白, Rat (HEK293, His)

CSF1R 蛋白, Rat (HEK293, His)

目录号: HY-P72955
COA 产品使用指南

CSF1R 蛋白是一种对多种多肽类生长因子、细胞因子，及激素具有高亲和性细胞表面受体。CSF1R 蛋白 参与 PLCG2/PKA/UCP2 信号通路减轻新生儿 HIE 大鼠模型中的氧化应激和神经元凋亡。CSF1R 信号的阻断与肿瘤发生有关。CSF1R 蛋白, Rat (HEK293, His) 是重组的 CSF1R 蛋白，由 HEK293 表达，带有 C-His 标签。CSF1R 蛋白, Rat (HEK293, His) 全长 491 个氨基酸，分子量为 69-89 kDa。

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100 μg ￥3800 In-stock
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描述

CSF1R Protein is a cell surface receptor with high a affinity for a variety of polypeptide growth factors, cytokines, and hormones. CSF1R Protein participate in PLCG2/PKA/UCP2 signaling pathway to reduce oxidative stress and neuronal apoptosis in rat models with neonatal HIE. The blocking of the CSF1R signal is associated with tumorigenesis. CSF1R Protein, Rat (HEK293, His) is the recombinant rat-derived CSF1R protein, expressed by HEK293 , with C-His labeled tag. The total length of CSF1R Protein, Rat (HEK293, His) is 491 a.a., with molecular weight of 69-89 kDa.
研究背景

Receptor protein-tyrosine kinase 是一种对多种多肽类生长因子、细胞因子，及激素具有高亲和性细胞表面受体。与人 CSF1R (集落刺激因子 1 受体) 同源。CSF1R 具有巨噬细胞集落刺激因子受体活性、蛋白同型二聚化活性和和蛋白磷酸酶结合活性。CSF1R 参与破骨细胞分化的正向调节以及骨吸收的调节。CSF1R 参与 PLCG2/PKA/UCP2 信号通路减轻新生儿 HIE 大鼠模型中的氧化应激和神经元凋亡。CSF1R 信号的阻断可抑制肿瘤浸润性髓样细胞，提高前列腺癌放疗疗效。在 INS-1E beta-cells中，通过 CSF1R/IRR 受体构建激活 Erk1/2磷酸化。
生物活性

Immobilized rat CSF1R-His at 10 μg/mL (100 μl/well) can bind biotinylated human CSF1-His, The EC50 of biotinylated human CSF1-His is 7.8-18.3 ng/mL.
种属

Rat
表达系统

HEK293
标签

C-His
蛋白编号

D4ACA7 (A64-E554)
基因 ID
蛋白结构
N-term
CSF1R (L21-L510)
Accession # D4ACA7
His
C-term
同用名
Macrophage colony-stimulating factor 1 receptor; CSF-1R; M-CSF-R; CD115; CSF1R; FMS
氨基酸序列

APVIEPSGPELVVEPGATVTLRCVSNGSVEWDGPISPYWTLDSESPGSILITKNATFKNTGTYRCTELEDPMRGSTAIHLYVKDPVRPWNLLAQEVTVFEGQEAVLPCLITDPTLKDSVSLVREWGRPVSRKTVYSFLPWRGFIIHKAKFLDSHTYMCKAVVNARESTSIGIRLKVNRAHPGPPHIILEPTKLVRIRGEAAQIVCSATHSEVEFNVILKRGDTKLEIPINSDFQDNAYKKVLTLNLNAVDFQDAGIYSCVANNAAGSNTATMNFQVVESAYLNLTSEQSLLQEVSVGENLDLTVIADAYPGLQRYNWTYLGPFFEDPHNLEFRTQWTTYSYSFKLHLNRVKPLEAGRYSLMAQNKAGWNNLTFELTLRYPPEVSVTWIPVNGSDVLLCDVSGYPQPNVTWMECRGHTDRCDEAQASQVWDDTQPEVLSQKPFHRVILQSQLPIGTLKHNMTYVCRAHNNVGNSSQFFRAISLGQSKQLPDE

分子量

69-89 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE
性状

溶液
组分

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
内毒素含量

<1 EU/μg, determined by LAL method.
复溶方法

N/A.
保存条件 & 期限

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
运输条件

Shipping with dry ice.
文件资料

COA (147 KB)

产品使用指南 (1213 KB)

CSF1R Protein, Rat (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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