CTLA-4 蛋白, Guinea pig (P.pastoris, His)

CTLA-4 protein, a potent inhibitory receptor, plays a crucial role in suppressing T-cell responses by binding strongly to its ligands CD80 and CD86, surpassing the affinity of CD28. This heightened affinity allows CTLA-4 to act as a major negative regulator, maintaining immune homeostasis and preventing excessive T-cell activation. The balance between CTLA-4 and its ligands is pivotal for immune regulation. CTLA-4 Protein, Guinea pig (P.pastoris, His) is the recombinant CTLA-4 protein, expressed by P. pastoris , with C-6*His labeled tag. The total length of CTLA-4 Protein, Guinea pig (P.pastoris, His) is 125 a.a., with molecular weight of ~18.0 kDa.

CTLA-4 蛋白作为一种重要的抑制性受体，在抑制 T 细胞反应中发挥着至关重要的作用。其抑制作用源于 CTLA-4 与其天然 B7 家族配体 CD80 和 CD86 表现出的极强亲和力，超过了其对应的刺激性辅助受体 CD28 的亲和力。凭借这种增强的亲和力，CTLA-4 在 T 细胞激活和免疫反应的复杂协调中充当主要的负调节因子。CTLA-4 及其配体介导的刺激信号和抑制信号之间的微妙平衡对于维持免疫稳态和防止 T 细胞过度或异常激活至关重要。

The ED₅₀ as determined by its ability to bind Mouse B7-1 in functional ELISA is less than 0.4 μg/mL.

Others

P. pastoris

C-6*His

H0VUB1 (A37-D161)

100725760  [NCBI]

AMHVAQPAVVLASSRGVASFECEYASSHNANEVRVTVLQQVASRTTEICAATYTVERELAFPEDSACAGTSSGTRVNLTIQGLRAADTGLYICKVELMYPPPYFVGTGNGTQIYVIDPEPCPDSD

16-35 kDa

• 
  Greater than 90% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.