2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Anti-infection
  3. P-glycoprotein Cytochrome P450 Bacterial Endogenous Metabolite
  4. Roquefortine C

Roquefortine C  (Synonyms: 异烟棒曲霉素 C)

目录号: HY-N6748 纯度: 98.42%
COA 产品使用指南

摩尔计算器

Roquefortine C 是一种从罗氏青霉分离的真菌环肽，可激活 P-gp 并抑制 P450-3A和其他血红蛋白。Roquefortine C 对革兰氏阳性细菌具有抑菌活性。

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Roquefortine C Chemical Structure

Roquefortine C Chemical Structure

CAS No. : 58735-64-1

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规格 价格 是否有货 数量
500 μg ￥3609
In-stock

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Customer Review

Roquefortine C 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Roquefortine C, a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins. Roquefortine C has bacteriostatic activities against Gram-positive bacteria[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BT-474 IC50
29.6 μM
Compound: 2; Roq C
Antiproliferative activity against human BT-474 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human BT-474 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 26692349]
MCF7 IC50
21.7 μM
Compound: 2; Roq C
Antiproliferative activity against human MCF7 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 26692349]
MDA-MB-231 IC50
23.5 μM
Compound: 2; Roq C
Antiproliferative activity against human MDA-MB-231 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 26692349]
MDA-MB-468 IC50
28.6 μM
Compound: 2; Roq C
Antiproliferative activity against human MDA-MB-468 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-468 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 26692349]
SK-BR-3 IC50
23.4 μM
Compound: 2; Roq C
Antiproliferative activity against human SK-BR-3 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human SK-BR-3 cells expressing c-MET assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 26692349]
分子量

389.45

Formula

C22H23N5O2
CAS 号
性状

固体

颜色

White to off-white

中文名称

异烟棒曲霉素 C
结构分类
初始来源

Penicillium roqueforti
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 10 mg/mL (25.68 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5677 mL 12.8386 mL 25.6772 mL
5 mM 0.5135 mL 2.5677 mL 5.1354 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.42%

COA (302 KB)

产品使用指南 (1538 KB)
参考文献

Roquefortine C 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5677 mL 12.8386 mL 25.6772 mL 64.1931 mL
5 mM 0.5135 mL 2.5677 mL 5.1354 mL 12.8386 mL
10 mM 0.2568 mL 1.2839 mL 2.5677 mL 6.4193 mL
15 mM 0.1712 mL 0.8559 mL 1.7118 mL 4.2795 mL
20 mM 0.1284 mL 0.6419 mL 1.2839 mL 3.2097 mL
25 mM 0.1027 mL 0.5135 mL 1.0271 mL 2.5677 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Roquefortine C58735-64-1异烟棒曲霉素 CP-glycoproteinCytochrome P450BacterialEndogenous MetaboliteP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243CYPsFungalcyclopeptidePenicilliumroquefortiiP450-3AhaemoproteinsbacteriostaticGram-positivebacteriaInhibitorinhibitorinhibit

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