2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Nelonemdaz potassium

Nelonemdaz potassium  (Synonyms: Salfaprodil; Neu2000 potassium)

目录号: HY-106408A 纯度: 99.86%
COA 产品使用指南

摩尔计算器

Nelonemdaz (Salfaprodil) potassium 是一种 NR2B 选择性和非竞争性的 N- 甲基 -D- 天冬氨酸 (NMDA) 受体拮抗剂，也是一种自由基清除剂。Nelonemdaz potassium 对 NMDA 和自由基诱导的细胞死亡具有出色的神经保护作用。

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Nelonemdaz potassium Chemical Structure

Nelonemdaz potassium Chemical Structure

CAS No. : 916214-57-8

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥2750
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1 mg ￥1136
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5 mg ￥2500
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10 mg ￥4500
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Other Forms of Nelonemdaz potassium:

Nelonemdaz potassium 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Nelonemdaz (Salfaprodil) potassium is an NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA). Nelonemdaz potassium is also a free radical scavenger. Nelonemdaz potassium has excellent neuroprotection against NMDA- and free radical-induced cell death[1][2].

IC50 & Target

NMDA[1]
体外研究
(In Vitro)

Nelonemdaz potassium (10-300 μM) shows apparent neuroprotection against 300 μM N-methyl-d-aspartate (NMDA) at doses as low as 30 μM[1].
Nelonemdaz potassium (10-500 μM) inhibits the electrophysiologic response of cultured cortical neurons to 300 μM NMDA in a concentration-dependent manner[1].
Nelonemdaz potassium (0.1-1 μM) produces a marked reduction of Fe2+-induced neurotoxicity, even at doses of 0.1 to 0.3 μM[1].
Nelonemdaz potassium (0.1-1 μM) blocks the degeneration of neurons and glia in cortical cell cultures[1].
Nelonemdaz potassium (0-350 μM) effectively scavenges superoxide radicals (IC50=63.07±1.44 μM), nitric oxide (IC50=155.8±4.88 μM), and hydroxyl radicals (IC50=58.45±1.74 μM)[3].
Nelonemdaz potassium (0.78-12.5 μM) decreases the amount of antimycin A-induced ROS/RNS formation in a dose-dependent manner, with an IC50 of 2.21±0.11 μM[3].
Nelonemdaz potassium (0.19-12.5 μM) inhibits malondialdehyde (MDA) formation with an IC50 of 2.72±0.26 μM[3].
Nelonemdaz potassium (0-125 μM) effectively reduces iron-ascorbate-induced lipid peroxidation (IC50=24.56±0.07 μM)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nelonemdaz potassium 相关抗体:
体内研究
(In Vivo)

Nelonemdaz potassium (0.5-20 mg/kg; i.v.) reduces cerebral infarct evolving 24 h after 60-mins occlusion of the middle cerebral artery occlusion (MCAO) substantially and dose dependently[1].
Nelonemdaz potassium (5 mg/kg; i.v.) protects white matter such as axons and myelin as well as gray matter from ischemic brain injury[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (260 to 300 g) (clip occlusion model)[1]
Dosage: 0.5-20 mg/kg
Administration: I.v. administration 5 mins after reperfusion
Result: Produced a large neuroprotective effect, with a maximal reduction in infarct volume of 66% at doses of 2.5 to 5 mg/kg.
Not observed neuronal damage in the most vulnerable cortical area after administration of 5 mg/kg.
Animal Model: Male Sprague-Dawley rats (260 to 300 g) (intraluminal thread occlusion model)[1]
Dosage: 5 mg/kg
Administration: I.v. administration 30 mins after reperfusion
Result: Did not change physiologic variables such as arterial pH, PCO2, PO2, and hematocrit.
Reduced infarct volume evolving in the cortex and the striatum substantially.
Reduced white matter damage in the striatum and external capsule markedly.
分子量

421.31

Formula

C15H7F7KNO3
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 200 mg/mL (474.71 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3735 mL 11.8677 mL 23.7355 mL
5 mM 0.4747 mL 2.3735 mL 4.7471 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Nelonemdaz potassium 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3735 mL 11.8677 mL 23.7355 mL 59.3387 mL
5 mM 0.4747 mL 2.3735 mL 4.7471 mL 11.8677 mL
10 mM 0.2374 mL 1.1868 mL 2.3735 mL 5.9339 mL
15 mM 0.1582 mL 0.7912 mL 1.5824 mL 3.9559 mL
20 mM 0.1187 mL 0.5934 mL 1.1868 mL 2.9669 mL
25 mM 0.0949 mL 0.4747 mL 0.9494 mL 2.3735 mL
30 mM 0.0791 mL 0.3956 mL 0.7912 mL 1.9780 mL
40 mM 0.0593 mL 0.2967 mL 0.5934 mL 1.4835 mL
50 mM 0.0475 mL 0.2374 mL 0.4747 mL 1.1868 mL
60 mM 0.0396 mL 0.1978 mL 0.3956 mL 0.9890 mL
80 mM 0.0297 mL 0.1483 mL 0.2967 mL 0.7417 mL
100 mM 0.0237 mL 0.1187 mL 0.2374 mL 0.5934 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nelonemdaz916214-57-8SalfaprodilNeu2000Neu 2000Neu-2000iGluRIonotropic glutamate receptorsNMDAneuroprotectionantioxidantfreeradicalscavengerInhibitorinhibitorinhibit

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